J. C. Dearden and G. M. Bresnen. The measurement of partition coefficients. Quant. Struct.-Act. Relat. 7:133-144 (1988).Dearden JC and Bresnen GM (1988) The measurement of partition coefficients. Quant Struct-act Rel 7: 133-144...
For radiolabeled compounds, radioactivity in each sample was quantified by measurement on MicroBeta (Perkin Elmer). For rosuvastatin, cell extracts were dried down under nitrogen and reconstituted in 50:50 (v:v) methanol:water prior to injection onto a LC-MS/MS system. The total cellular protein...
The BD2013 data set covered 6 species (including human, mouse, and macaque), 114 MHC-I alleles, 257 (MHC, length) data sets with 685 affinity measurements on average, and a total of 176,161 measurements. BD2013 is the largest binding affinity measurement data set assembled to date for ...
With more high dimensional complex data being readily accessible (e.g., repeated measurement data and imaging data in the electronic health records database), further research is needed to establish the clinical utility of neural network survival models and other machine learning/deep learning models...
The advantages and limitations of this direct measurement method are discussed. The use of this methodology provides a means to rapidly assess log D values for large compound arrays. 展开 关键词: partition coefficient log P log D high throughput physicochemical ...
method were selected. However, the sap flow method was not applicable for the grassland site; therefore, the transpiration data obtained from the Hydrus-1D model and site measurement data was used in this study. Second, only sites with at least one year of continuous flux measurements were ...
When the complexes were subjected to the measurement of an infrared spectrum by using a liquid cell 1 mm thick with KBr windows against chloroform as the reference, the reproducibility of this method was (1.1〜1.3)% as a coefficient of variation in the concentration ratio range of 0.1 to ...
Sufficient resolution of the MS instrument is essential for accurate measurement of CPs. Using a LRMS (e.g. quadrupole), analysis of CPs is potentially interfered with by PCBs, chlordane, toxaphene [13,56], and phthalates [127] among other substances. Perhaps more importantly, LRMS suffers se...
2c clearly shows that compared with daytime and nighttime populations, the AP achieves the highest [Math Processing Error]R2 in all cities ([Math Processing Error]⟨Rinfra|ap2⟩≈0.839), which demonstrates the effectiveness of the AP measurement. To investigate the super-linear scaling within...
However, with an increasing number of variables and different levels of measurement, it can be challenging to formulate the joint distribution of the data. Fully conditional specification offers a solution to this challenge by allowing a flexible specification of the imputation model for each partially...