内容提示: The MAPK Signaling CascadesR Seger and S Wexler, The Weizmann Institute of Science, Rehovot, Israelr 2016 Elsevier Inc. All rights reserved.GlossaryThe mitogen-activated protein kinase (MAPK)Cascadesare a central group of signaling pathways that respond to avariety of extracellular stimuli...
2. The MAPK signaling cascades and their functions 3. Nuclear functions of the ERK1/2 cascade 4. Nuclear functions of the other MAPK cascades 5. Mechanisms of ERK5 and ERK1/2 translocation into the nucleus 6. Summary Acknowledgements ReferencesShow full outline Cited by (726) Figures (2)Bi...
The MAPK signaling cascade - SEGER, KREBS - 1995 () Citation Context ...-clamp, an additional warm cardioplegia was given, followed by warm blood. Heart Biopsies and Preparation Biopsies (40 to 60 mg) were taken into liquid nitrogen at 3 time points during the operation: =-=(1)-=- ...
GTP-bound RAS activates the ERK1/2 signaling cascade. This consists of the MAPKKKs A-RAF, B-RAF, and RAF-1/C-RAF; the MAPKKs MEK1 and MEK2; and the MAPKs ERK1 and ERK2 (Fig. 1A). Once phosphorylated by MEK, ERK1/2 can then act on targets in the cytoplasm, such as a ...
Cell adhesion can promote drug resistance via multiple mechanisms; by inhibiting the apoptotic signaling cascade, enhancing drug efflux and activating DNA repair. These mechanisms are often simultaneously deregulated in drug resistant cells. Integrin-ECM interactions inhibit chemotherapy-induced apoptosis of ...
The mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling cascade contributes to synaptic plasticity and to long-term memory formation, yet whether MAPK/ERK controls activity-dependent gene expression critical for long-lasting changes at the synapse and what the event...
Six subfamilies of MAPKs have been extensively characterized in mammalian cells: ERK1/2, JNKs, ERK 3, p38s, ERK5 and ERK 7/8. Transmission of signals is normally achieved by sequential phosphorylation and activation of the components specific to a respective cascade. All MAPK cascades comprise...
Thus, basic molecular alterations, such as those caused by gain-of-function mutations in different components (JAK, STAT) and extensive expression (cytokine receptors, JAK), may result in aberrant activation of a signaling cascade. JAK2 acts as an essential mediator in HSCs by transmitting signals...
摘要: Ca2+ signaling and MAPK cascade are necessary for C. elegans sperm activation.The activation of JNK/p38 is sufficient to induce C. elegans sperm activation.The proper modulation of JNK/p38 activity is crucial for MSP-based sperm motility.关键词:...
MAPK Cascades as Feedback Amplifiers Interconvertible enzyme cascades, exemplified by the mitogen activated protein kinase (MAPK) cascade, are a frequent mechanism in signal transduction pathways. There has been much speculation as to the role of these pathways, and how the... HM Sauro,B Ingalls...