Brinkmann U, Kontermann RE. The making of bispecific antibodies. MAbs 2017; 9: 182-212.Brinkmann U and Kontermann RE. The making of bispecific antibodies. MAbs 2017; 9: 182-212.Brinkmann U, Kontermann RE. The making of bispecific antibodies. MAbs. 2017;9(2):182-212....
The term bispecific antibody (bsAb) is used to describe a large family of molecules designed to recognize two different epitopes or antigens. BsAbs come in many formats, ranging from relatively small proteins, merely consisting of two linked antigen-binding fragments, to large immunoglobulin G (Ig...
Bispecific antibodies (bsAbs) target two different epitopes. These are an up-and-coming class of biologics, with two such therapeutics (emicizumab and blinatumomab) FDA approved and on the market, and many more in clinical trials. While the first reporte
Advances in biotechnology have improved the production and recombination of antibodies, leading to improvements in mAb therapies.3 One promising approach to improving mAbs, specificity for tumor cells, is through the dual binding mechanism of bispecific antibodies (bsAbs). Unlike conventional mAbs, which...
As bispecific antibodies have already been shown to be effective in vivo in experimental tumor systems as well as in phase-one clinical trials, the small... Mack,Riethmüller,Kufer - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 484发表: 1995年...
Bispecific human IgG by design A major obstacle facing the development of bispecific antibodies as therapeutics has been the formidable task of producing these complex molecules in suffi... P Carter - 《Journal of Immunological Methods》 被引量: 301发表: 2001年 Bispecific antibody heterodimers Methods...
home / around-the-practice / bispecific-antibodies-in-the-treatment-of-multiple-myeloma-expert-and-patient-perspectives A panel of experts joins Anne-Marie Jacob, a patient with multiple myeloma, to discuss the treatment of multiple myeloma with bispecifics and their pers...
neutralizing human antibodies from human B cells has also yielded promising results for infectious disease therapeutics. The recent development of bispecific antibodies offers attractive new opportunities for the design of novel protein therapeutics. A bispecific antibody can be generated by utilizing protein...
Bispecific antibodies have moved from being an academic curiosity with therapeutic promise to reality, with two molecules being currently commercialized (H
Studies of breast cancer therapy have examined the improvement of bispecific trastuzumab/pertuzumab antibodies interacting simultaneously with two different epitopes of the human epidermal growth factor receptor 2 (HER2). Here, we describe the creation and production of plant-made bispecific antibodies based...