The major categories of immunotherapy. Different forms of cancer immunotherapy, including oncolytic virus therapies, cancer vaccines, cytokine therapies, adoptive cell transfer, and immune checkpoint inhibitors, have evolved and shown promise in clinical practice. The basic principles of each strategy and ...
diagnosis of cancer and other diseases. The application of liquid biopsy provides a new possible solution, as it has several advantages such as non-invasive, real-time dynamic monitoring, and overcoming tumor heterogeneity. Liquid biopsy has shown predictive value in immunotherapy, significantly improvin...
Understanding the mechanistic effects of novel immunotherapy agents is critical to improving their successful clinical translation. These effects need to be studied in preclinical models that maintain the heterogenous tumor microenvironment (TME) and dys
A promising strategy of combining with low-dose radiotherapy to enhance the efficacy of immunotherapy. • Recent clinical trials and evidence supporting this combination strategy. Abstract Progress in the treatment of small cell lung cancer (SCLC) has been modest over the past decades until the adv...
Cancer is a malignant tumor that seriously threatens human life and health. At present, the main treatment methods include surgical resection, chemotherapy, radiotherapy, and immunotherapy. However, the mechanism of tumor occurrence and development is complex, and it produces resistance to some tradition...
restrain the Nrf2/HO-1 pathway, thus preserving cellular antioxidant balance [119]. Collectively, these studies unequivocally establish that Nrf2 serves as a major negative regulator of ferroptosis in ALI, and that ferroptosis itself contributes to the progression of ALI. In this review, we ...
Cancer vaccines and other forms of immunotherapy represent promising new approaches in the war against the disease [206]. Tumor-associated antigens, such as growth-associated factors or antigens that are unique to malignant cells as a result of somatic mutation, can be used in the development of...
Hence, biomarkers of synapse damage and loss, especially the use of multiple categories of biomarkers in combination with one another, hold great promise as biological measures that should correlate with cognitive function in AD. Availability of data and materials The datasets used and/or analyzed ...
immunotherapy, we describe two categories of approaches to the design of novel drugs and combination therapies: the first involves direct modification of the tumor, while the second indirectly enhances immunogenicity through alteration of the microenvironment. By systematically addressing the factors that ...
(Fig.5a, Supplementary Fig.12a, and Supplementary Table1). Based on marker genes of immune cells, six major categories of immune cells were identified in the tumor microenvironment, including B cells (CD19+), CD4 + T cells (CD3e + CD4 + ), CD8 + T cells (CD3e ...