Protein Biology Resource Library Pierce Protein Methods Immunoprecipitation (IP) is the small-scale affinity purification of antigens using a specific antibody that is immobilized to a solid support such as magnetic particles or agarose re...
Collectively, our work provides a comprehensive resource for decoding the aging process of microglia, shedding light on how microglia maintain brain functions.Similar content being viewed by others Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the ...
1a). DPL-1 and EFL-1 form the E2F–DP heterodimer, which directly contacts promoters by binding to the cycle-dependent element (CDE). E2F–DP is linked through the pocket protein LIN-35 to the MuvB subcomplex, which binds the cell cycle genes homology region (CHR) in promoters to then...
These results suggest that basal activity of CREB is required for the mitogenic signaling of EGF in NSCs at a level between ERK activation and SRE-mediated transcriptional activation. 展开 关键词: EGF cAMP response element-binding protein proliferation immediately early gene ...
1c), and as a meristem is capable of continuous cell division [50]. After co-culture with Agrobacterium for 48 h under 19℃, the GFP (green-fluorescent protein) and RFP (red-fluorescent protein) under the transcriptional control of CaMV-35S promoter expression was detectable in the primary...
This motif was identified as a conserved motif that appeared in tomato light-harvesting complex protein genes (Lhc) promoters which are expressed under the control of a circadian clock (Piechulla et al., 1998). Moreover, EE, a cis-element with the consensus sequence of AAAATATCT and known ...
In recent years, however, improved western blot technology and technique have allowed an exciting quantitative element to emerge. Researchers can now reliably measure relative changes in protein expression and abundance. But with this shift towards quantitative understanding comes a movement by major journ...
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Hippocampal place cells represent the position of a rodent within an environment. In addition, recent experiments show that the CA1 subfield of a passive observer also represents the position of a conspecific performing a spatial task. However, whether this representation is allocentric, egocentric or...
Cancer cells often co-opt post-transcriptional regulatory mechanisms to achieve pathologic expression of gene networks that drive metastasis. Translational control is a major regulatory hub in oncogenesis; however, its effects on cancer progression remain poorly understood. Here, to address this, we use...