The structure of double helical Hexitol Nucleic Acidsdoi:10.1107/S0108767300025873R DeclercqLuc Meervelt
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Nucleosomes are formed by histone octamers consisting of two heterodimers H2A/H2B and one tetramer, (H3/H4)2wrapping ~145/147 base pairs of DNA ~1.7 times around them in a left-handed supercoil with an average radius of curvature of 9 nm. The way in which a DNA sequence can intrinsi...
Chemical carcinogens can react with nucleic acids and proteins. Until now, most of the works have been devoted to the reaction with DNA. The covalent binding of the carcinogens to DNA can modify the conformation of DNA and consequently the interactions between the modified DNA and some proteins....
To confirm the apoptosis, double stranded DNA fragmentation was quantitatively evaluated by TUNEL assay using flow cytometry. By this assay which is a classical method for detection of DNA breakage by labeling the terminal end of nucleic acids, the effect of treatment of MDA-MB-231 cells with IC...
PXXP motifs most often adopt a left-handed type II polyproline (PPII) helix conformation and bind to a canonical hydrophobic pocket located between two short loops of the target SH3 domain, the so-called RT and the n-Src loops (5, 6). The partner can interact with the SH3 protein in...
The respiratory syncytial virus nucleoprotein-RNA complex forms a left-handed helical nucleocapsid. J. Gen. Virol. 2013, 94, 1734–1738. [Google Scholar] [CrossRef] Galloux, M.; Tarus, B.; Blazevic, I.; Fix, J.; Duquerroy, S.; Eleouet, J.F. Characterization of a viral ...
(a) With four cysteines, two different connectivities can lead to either a “globular” structure with 𝛼α-helical content (left, PDB 1PEN for conotoxin 𝛼α-PnIA [72]) or a flattened “ribbon” structure which often, but not always, displays 𝛽β-sheet content (right, PDB 2EW4...
Molecular structure of a left-handed double helical DNA fragment at atomic resolution Nature, 282 Jay Gralla,Donald Crothers(1973) Free energy of imperfect nucleic acid helices. 3. Small internal loops resulting from mismatches. Journal of molecular biology, 78 2 ...
Basis for the right-handed helical sense of double-stranded DNA: formation of the right-handed helix by L-oligonucleotides fixed in low-anti glycosyl confo... (2001) Basis for the right-handed helical sense of double-stranded DNA: formation of the right-handed helix by l-oligonucleotides ...