Meanwhile, mutations inSTAG2as well asRAD21, a core component of cohesin complex at the centromere crucial for holding the centromeres of sister chromatids together from the time of DNA replication in S phase until their segregation in mitosis, also cause premature separation of sister chromatids...
A structure in all living cells that carries the genes that determine heredity. In all cells except bacterial cells, the chromosomes are thread-like strands of DNA and protein that are contained in the nucleus. They occur in pairs in all of the cells of eukaryotes except the reproductive cells...
The lesions that lead to sister chromatid exchanges are different from those that lead to chromosome aberrations: S. Wolff, Laboratory of Radiobiology and Department of Anatomy, University of California, San Francisco, Cal. 94143 (U.S.A.)
are required to result in four daughter cells, while meiosis produces four daughter cells with just one synthesis phase. If resources are depleted, then organisms have problems to continue mitotic cell divisions because homologous recombinational repair with sister chromatids is too costly. If at ...
Women are born with all of their oocytes. The oocyte proteome must be maintained with minimal damage throughout the woman’s reproductive life, and hence for decades. Here we report that oocyte and ovarian proteostasis involves extreme protein longevity. Mouse ovaries had more extremely long-lived...
Although several analytical methods for the determination of PhACs in biological matrices have been developed in the last decade, there is still a need for improvement toward the higher sensitivity of used instruments and accuracy of analytical methods, particularly for liver samples that are loaded wi...
作者: S Wolf 摘要: If cells are irradiated during most of the G 1 portion of the cell cycle, chromosome aberrations are produced. If, however, they are irradiated while in S or G 2, chromatid aberrations are formed. The best estimate of when the transition occurs is late G 1. That ...
Sixty years of chromatin aggregation studies: from insoluble precipitants to phase-separated condensates In 1957, Oth and Desreux [9] reported that endogenous preparations of chromatin are disperse in low ionic strength buffers but form high molecular weight aggregates in 0.15–0.4 M NaCl. At the...
The B6.YTIR (XY) mouse develops bilateral ovaries despite the expression of the testis-determining gene Sry during gonadal differentiation. We reported that the oocytes of the XY female are defective in their cytoplasm, resulting in a failure in the seco
1)11. It has been reported that hnRNPs are mostly located in the nucleus under steady-state conditions; however, they can be localized in diverse compartments in cells with distinct sequence binding affinities depending on their specific structures and intrinsic functions10,26,27. It has also ...