The gut microbiome is a key player in the immunomodulatory and protumorigenic microenvironment during colorectal cancer (CRC), as different gut-derived bacteria can induce tumour growth. However, the crosstalk between the gut microbiome and the host in relation to tumour cell metabolism remains largely...
Ageing-associated functional decline of organs and increased risk for age-related chronic pathologies is driven in part by the accumulation of senescent cells, which develop the senescence-associated secretory phenotype (SASP). Here we show that procyanidin C1 (PCC1), a polyphenolic component of grap...
K1268 Is Required for UV-Induced RPB1 Poly-ubiquitylation and Degradation A small subset of RNAPII molecules that arrest at DNA lesions is ubiquitylated on their largest subunit, RPB1 (POLR2A), yet the functionally important sites of ubiquitylation are unknown. To chart these sites, we overlapped...
who were focused on Turonian flint knapping. Lithic inventory records collecting of several local flint varieties at the distance up to around 20 km from the site, followed by almost all stages of flint working. The material from Stare Baraki is the first known and ...
Tang et al. (2009) were the first to attempt a multigene phylogeny derived from a combination of rRNA and protein-coding genes. Besides ITS, LSU, and TUB2, Tang et al. used the section “6–7” of the second largest subunit of the RNA-polymerase II gene (RPB2) that is commonly use...
Cercarial dermatitis, colloquially “swimmer’s itch”, is a rash contracted in natural bodies of water, when people are exposed to skin-penetrating, larval flatworm parasites of the family Schistosomatidae, that emerge from aquatic snails. Swimmer’s it
The other two large-scale duplications involved the largest subunit (~64 kb, second box in Figure 2); one occurred between LCR22-3a' and LCR22-4', and the other at the distal half of LCR22-4' (Figure 3C). Further syntenic analysis (described above) showed that the duplication between...
This is the largest assembly in which every subunit is in an identical environment. (B) Schematic representation of the subunit building block found in many RNA viruses, known as the eightfold β barrel or β sandwich. The β sheets, labeled B through I from the N terminus of the protein,...
This is the largest GWAS directly studying long-lived participants (aged ≥90 years) compared with shorter-lived (<65) controls to date. Article PubMed PubMed Central CAS Google Scholar Nikpay, M. et al. A comprehensive 1,000 genomes-based genome-wide association meta-analysis of coronary ...
At) contains only one genetic isoform for each Lhca subunit (see “Materials and methods”; Supplementary Fig.S5). Considering the high sequence similarity for each group of the Lhca isoforms, the question is which isoform is selected for building thePpPSI–LHCI, or can some of the Lhca ...