The year 2023 marks the mid-point of the 15-year period envisaged to achieve the Sustainable Development Goals, targets for global development adopted in September 2015 by all United Nations Member States. To help track where we are on this journey, and to amplify success stories, in this ...
et al. Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53. Science 349, 1261669 (2015). Article PubMed PubMed Central CAS Google Scholar Fulda, S. et al. Activation of the CD95 (APO-1/Fas) pathway in drug- and γ-irradiation-induced apoptosis of ...
GPCRs have been a longstanding topic of interest in the Journal of Biological Chemistry, and here we will expand on the impact of GPCRs in cancer biology. This review will summarize the current knowledge of how GPCRs are altered in cancer and how these aberrations can contribute to cancer ...
select article Efgartigimod: Potential Impact on IVIG Therapy EditorialNo access Efgartigimod: Potential Impact on IVIG Therapy Jeffrey G. Demain, Francisco A. Bonilla July 2022 Page 1930 select article Atopy as Immune Dysregulation: Offender Genes and Targets ...
To determine the impact of individual B-cell subtypes on the prognosis of patients with MIBC, we developed a risk prognostic model. The genes identified through LASSO analysis within B-cell subtypes are provided in Additional file 3: Table S2. The infiltration of B-STMN1, B-CD69, Plasma-MZB...
of the drug itself, as well as the hepatic first-pass effect, the irritating effects of the drug on the gastric mucosa, and the impact of food present within the gastrointestinal tract [20]. Furthermore, the active ingredients of the drug may be compromised by digestive enzymes and gastric ...
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China 2. State Key Laboratory of Stem Cell and Reproductive Biology, Ins...
Impact of family history on prostate cancer mortality in white men undergoing prostate specific antigen based screening. J Urol. 2015;193(1):75-79.PubMedGoogle ScholarCrossref 45. Bokhorst LP, Zhu X, Bul M, Bangma CH, Schröder FH, Roobol MJ. Positive predictive value of prostate biopsy...
It carries a signal from cytokines, interleukins, and growth factors that impact transmembrane receptors, such as the family of epidermal growth factor receptors (EGFR) [57]. The binding of a ligand induces a conformational change in the receptor what causes the positioning of receptor-associated ...
Moreover, γδT cells constitute about 40% tumor infiltrating T cells in human PDAC, which are considered major sources of immune suppressive checkpoint ligands [24]. KRAS can increase granulocyte-macrophage colony-stimulating factor (GM-CSF) expression in mouse pancreatic ductal epithelial cells, ...