The integrated stress response (ISR) is an essential stress-support pathway increasingly recognized as a determinant of tumorigenesis. Here we demonstrate that ISR is pivotal in lung adenocarcinoma (LUAD) development, the most common histological type of lung cancer and a leading cause of cancer ...
The integrated stress response primarily suppresses protein translation initiation. However, whether the integrated stress response regulates other steps of protein translation, such as elongation, termination, and ribosome recycling, is not known. Although the integrated stress response generally imposes globa...
In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2α) by one of four...
Senescence suppresses the integrated stress response and activates a stress-remodeled secretory phenotype Author links open overlay panelMatthew J. Payea 1, Showkat A. Dar 1, Carlos Anerillas 1, Jennifer L. Martindale 1, Cedric Belair 1, Rachel Munk 1, Sulochan Malla 1, Jinshui Fan 1, ...
Most, if not all, underlying pathological changes, including oxidative stress, inflammation, and nutrient deprivation, are potent inducers of the integrated stress response (ISR). Four upstream kinases are involved in ISR signaling that sense a myriad of input stress signals and converge on the ...
Autophagy modulates amino acid signaling network in myotubes: differential effects on mTORC1 pathway and the integrated stress response Induction of autophagy and the integrated stress r Long,Yun,Chau,... - 《Faseb Journal》 被引量: 10发表: 2015年 The integrated stress response in budding yeast ...
We explored whether mutation-induced (F508del) misfolding of the cystic fibrosis transmembrane conductance regulator (CFTR), and/or secondary colonization with opportunistic pathogens, activate tissue remodeling and innate immune response drivers. 关键词: Cystic fibrosis F508del-CFTR ER stress Tissue ...
Healthy aging requires the coordination of numerous stress signaling pathways that converge on the protein homeostasis network. The integrated stress response (ISR) is activated by diverse stimuli, leading to phosphorylation of the eukaryotic translation initiation factor eIF2 in its α-subunit. Under re...
The integrated stress response (ISR) allows cells to rapidly shutdown most of their protein synthesis in response to protein misfolding, amino acid deficiency, or virus infection. These stresses trigger the phosphorylation of the translation initiation factor eIF2alpha, which prevents the initiation of...
The integrated action of these stress response and maintenance systems has been optimized in the early years of life to maximize fitness. Many studies suggest, however, that a decline in the effectiveness and integration of stress responses contributes to aging and age-related diseases. One of the...