The Inflammatory Response to Cell Death When cells die in vivo, they trigger an inflammatory response. The ensuing hyperemia, leak of plasma proteins, and recruitment of leukocytes serve a number... KL Rock,H Kono - 《Annual Review of Pathology》 被引量: 704发表: 2008年 Uric acid promotes...
Cell death can be both a consequence and a cause of inflammation, which can be difficult to distinguish in chronic diseases. Despite this caveat, excessive or poorly regulated cell death is increasingly recognized as a contributor to chronic inflammation in rheumatic disease and other inflammatory ...
Cell death occurs when a pathogen invades a host organism or the organism is subjected to sterile injury. Thus, cell death is often closely associated with the induction of an immune response. Furthermore, cell death can occur as a consequence of the imm
Our results show that, when confronted with this pathogen, macrophages respond through a pro-inflammatory response and microbicidal action to destroy the infectious agent. However, at the same time, the increase of a pro-inflammatory response following the bacterial processing promotes the clearance of...
Cell death during sepsis: integration of disintegration in the inflammatory response to overwhelming infection Cell death during sepsis: integration of disintegration in the inflammatory response to overwhelming infection[J] . Fabiano Pinheiro da Silva,Victor Nizet... ...
61Pathogens causing cell death via caspase-1 activation also induce the production of IL-1β and IL-18. These cytokines play a central role in the inflammatory response to infection by recruiting immune cells and inducing further production of cytokines.62Their cleavage and release, however, are ...
Indeed, IL-1β plays an orchestrating role in the inflammatory response to myocardial injury, including enhanced synthesis of other proinflammatory mediators, activation of profibrotic pathways (5), and promotion of cytokine-induced cardiomyocyte apoptosis (9) but also exerts direct negative inotropic ...
that IFN-α reduces the birth of new brain cells and increases brain cell death in the hippocampus. The researchers demonstrated this by regulating the levels of four inflammatory proteins, which are known to activate the immune response and to regulate distinct brain functions related to depression...
Bidirectional regulation of NF-κB by reactive oxygen species: a role of unfolded protein response. Free Radic. Biol. Med. 65, 162–174 (2013). Article CAS PubMed Google Scholar Janus, P. et al. Pro-inflammatory cytokine and high doses of ionizing radiation have similar effects on the ...
Thus, apop- tosis does not induce an inflammatory response and is considered to be immunologically silent. Several pathogens have been reported to trigger apoptosis. This is accomplished through different mechanisms including the production of bacterial toxins or expression of virulence factors that ...