43 It has been hypothesized that the NMDAr, situated between the primary and secondary glutamatergic cortical neurons, constitutes the main deficit underlying schizophrenia. Poor function of the NMDAr, in turn, renders the gamma-amino-buteric-acid (GABA)-ergic interneuron less effective. This loss ...
The Fountain Villa / Mjölk architekti The Pink Zebra Restaurant / Renesa Architecture Design Interiors Studio Tree-ness House / Akihisa Hirata 6 Small Scale Projects with Large Social Impact Fitzroy North House 02 / Rob Kennon Architects Screen Pavilion / Ray&Emilio Studio House in Iiz...
This function is mediated by a nuclear matrix association sequence, which consists of a conserved motif in the C-terminus and the adjacent nucleolar localization signal (NoLS). Conclusion These results add further insight into the evolution and function of proteins of the SAP30 family, which share...
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Nguyen LK, Kolch W, Kholodenko BN. When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling. Cell Commun Signal. 2013;11:1–15. Article Google Scholar Müller S, Hoege C, Pyrowolakis G, Jentsch S. SUMO, ubiquitin’s mysterious cousin. Nat Rev Mol ...
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Microbiome-metabolome studies of the human gut have been gaining popularity in recent years, mostly due to accumulating evidence of the interplay between gut microbes, metabolites, and host health. Statistical and machine learning-based methods have been widely applied to analyze such paired microbiome...
The TGF-β signaling pathway governs key cellular processes under physiologic conditions and is deregulated in many pathologies, including cancer. TGF-β is a multifunctional cytokine that acts in a cell- and context-dependent manner as a tumor promoter
No other bacterial genus has been brought into context with so many different aspects of public interest as that of Pseudomonas (439): Pseudomonas aeruginosa is the germ responsible for most hospital infections (40a) being increasingly resistant against
1: Our study reveals a novel feedback loop between the Hippo pathway and CXCR7 in coordinating tumorigenesis in gastric cancer. 2: Our study reveals that blockade of CXCR7, which impedes membrane signal transduction, could be a promising strategy for gastric cancer therapeutics. 3: Our model th...