whereas epigenetics is responsible for studying the changes in gene function that are hereditary and cannot be attributed to alterations in the DNA sequence; Epigenetics has become an important part of the development and normal functioning of cells, by means of which it is possible to arrive at ...
is estimated in at least 50% of all cancer cases, and contributes to cellular growth by preventing proper G1-S checkpoint control [25]. Cytoplasmic p53 is localized to the nucleus in response to DNA damage through interactions between its nuclear localization signal regions and the importin\(\a...
These data elucidate the importance of epigenetics marks in the cancer cell reprogramming induced by stromal cell and indicated that the interpreters of the DNA methylation signal have a major role in the response of the cancer cells to the microenvironment. Similar content being viewed by others ...
An explosion of data indicating the importance of epigenetic processes, especially those resulting in the silencing of key regulatory genes, has led to the realization that genetics and epigenetics cooperate at all stages of cancer development. Recent advances include the understanding that silencing is...
While these findings demonstrated the importance of epigenetics for phenotypic characterization and perception of CHO cells, a deeper understanding of the general mechanism of epigenetic expression regulation was still lacking. In 2015, Wippermann et al. (2015) demonstrated that repression by DNA ...
Our studies reveal the importance of epigenetics in regulatingVSGgenes and provide new insights toward the understanding of this unique survival device. ... LM Figueiredo,CJ Janzen,GAM Cross,... - 《Plos Biology》 被引量: 212发表: 2008年 Long non-coding RNAs are expressed in oral mucosa and...
Gut microbiota and allergy: the importance of the pregnancy period. Limited microbial exposure is suggested to underlie the increase of allergic diseases in affluent countries, and bacterial diversity seems to be more important than specific bacteria taxa. Prospective studies indicate that the gut micro...
Indeed, E proteins E2A and HEB both bind strongly near multiple Trav15 elements and the importance of this binding was revealed by the impairment of Vγ1.1Vδ6.3 NKγδT cell development upon disruption of the E-box(es) downstream of the Trav15d-1-dv6d-1 RSS. This finding indicates ...
Recently the influence of the environment in development and physiology has been underlined. Gene × environment interactions determine how individuals with the same or different genotypes will respond to environmental variation. The importance of epigenetics in environmental responses is well-established in...
The importance of NF-Y in stress tolerance was demonstrated by overexpressing a citrus NF-YA5 in transgenic tobacco showing improved dehydration tolerance58. Translation is one of the important steps in eukaryotic gene expression/protein synthesis, which is classically divided into three steps: ...