The goal of this review is to organize currently available data on the mechanisms that control the initiation of DNA replication in human cells.doi:10.1016/j.dnarep.2018.09.003Moiseeva Tatiana N.Bakkenist Christopher J.DNA Repair
What is the purpose of DNA helicase in the DNA replication process? Why is DNA replication necessary? What is the purpose of a primer during DNA replication? What is DNA replication? What is its importance? (a) What is the purpose of supercoiling? (b) How it is done in replication and...
When a cell grows and divides to give rise to genetically identical cells, the genome of the cell is duplicated prior to cell-division. The process of genomic duplication is called DNA replication, and is closely coordinated with other processes in the cell, such as growth rate, and cell div...
Cell Cycle Regulation of DNA Replication Eukaryotic DNA replication is regulated to ensure all chromosomes replicate once and only once per cell cycle. Replication begins at many origins scattered... RA Sclafani,TM Holzen - 《Annual Review of Genetics》 被引量: 663发表: 2007年 Co-evolution of ...
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The nature of such modular, combinatorial regulation of DNA replication at the genetic and epigenetic levels remains to be revealed. Previous studies applied stepwise reverse engineering approaches to probe for mechanisms controlling replication timing. However, such a complex system may be best studied ...
The initiation of DNA replication in eukaryotic is a highly regulated process that leads to the duplication of the genetic information for the next generat... B Stillman - 《Science》 被引量: 1482发表: 1996年 Regulation of DNA-replication origins during cell-cycle progression. We have shown pre...
The DNA replication priming protein, PriA, is required for homologous recombination and double-strand... The PriA protein, a component of the phiX174-type primosome, was previously shown to be essential for damage-inducible DNA replication in Escherichia coli,... T Kogoma,GW Cadwell,KG Barnard...
DNA Replication:DNA replication is the process of formation of new DNA strands from the existing parent DNA. DNA replication takes place in the nucleus during the cell division with the help of several enzymes like polymerases, helicase, and ligase....
Accurate chromosomal DNA replication is essential to maintain genomic stability. Genetic evidence suggests that certain repetitive sequences impair replication, yet the underlying mechanism is poorly defined. Replication could be directly inhibited by th