The judicious integration of these advances may unlock the promise of biologically targeted mRNA therapeutics, beyond vaccines and other immunostimulatory agents, for the treatment of diverse clinical indications.This is a preview of subscription content, access via your institution ...
is very effective in dissociating the affinity interactions upon which IP is based. Other downstream applications for IP products are not compatible with this buffer system, nor is it possible to take advantage of certain IP methods, s...
Regulatory T cells (Tregs) are also a key part of the adaptive immune system that act as a critical off switch. They keep the immune response in check by suppressing the activity of T Cells to ensure that the immune system doesn’t overreact and attack self-antigens or other non-threateni...
Tissues are the new frontier of discoveries in immunology. Cells of the immune system are an integral part of tissue physiology and immunity. Determining how immune cells inhabit, housekeep, and defend gut, lung, brain, liver, uterus, and other organs helps revealing the intimate details of tiss...
Other necessary data and full details can be found in the supporting information file.Abbreviations AMP: Antimicrobial peptides KA: Known AMPs PA: AI-predicted AMPs References Klein EY, Milkowska-Shibata M, Tseng KK, et al. Assessment of WHO antibiotic consumption and access targets in 76...
Owing to the specificity of the linear deubiquitination of OTULIN, it remains unclear how OTULIN deficiency leads to an increase in other ubiquitin chains on GPX4, such as K48 and poly-Ub, in addition to linear ubiquitination. Nevertheless, our work revealed a role for OTULIN in regulating ...
including immune system development and activity, host metabolism, and even brain function [1,2,3,4]. Several recent studies have also established a causal link between microbially produced metabolites and various medical conditions (or benefits). One well-known example is that of trimethylamineN-ox...
can be activated in epithelial cells by microbial components and lead to the initiation of an immune response through chemokine secretion54. Upregulated genes in the COVID-19 DTA+-like population were enriched for genes related to cytokine signaling in the immune system (Fig.4i), and several ...
Cell surfaces in the immune system are richly equipped with a complex mixture of glycans, which can be recognized by diverse glycan-binding proteins. The Siglecs are a family of sialic-acid-binding immunoglobulin-like lectins that are thought to promote cell–cell interactions and regulate the func...
and function in health and disease. Such studies are increasing our understanding of the microbiome’s impact on the immune response and other physiological processes, and further enabling a shift from correlation to causation, with emerging insights into how this data can be utilized for diagnostic...