Your immune system is the guardian of your galaxy, protecting your body from all sorts of germs and invaders. From your skin to tiny cells, use WebMD's slideshow to learn about the parts of your immune system, what they do, how they work together, and wh
(2) positive selection for engraftment, and (3) negative selection by the immune system. Drift can be due to random sampling of few related clones from the initial population, and would have the effect of increasing the number of the clonal composition of the transplanted tumors. The same eff...
In this Timeline article, Shigekazu Nagata and Masato Tanaka highlight some of the key discoveries that have shaped the field of programmed cell death over the past 50 years and explain their relevance for the immune system. More than 50 years ago, cells
Aging of the immune system, also referred to as immunosenescence, describes the age-related changes in immune function that lead to increased susceptibility of older people to infectious diseases, autoimmunity, and cancer. The capacity of the immune system to mount an adequate response decreases with...
124 Immune checkpoints are mediators of the immune system that avert the immune system from the non-selective invasion of self-antigens. From: Clinical Immunology, 2023 About this pageAdd to MendeleySet alert Also in subject area: Medicine and DentistryDiscover other topics ...
Disrupting beta cells’hla expression is not the only possible approach to deflecting the adaptive immune system. Hasna Maachi of the Technical University of Munich, in Germany, described to the meeting how she and her mentor, Matthias Hebrok, are trying to develop an alternative. This introduces...
This might be explained by quiescent adult epicardial cells being less responsive to EMT-driving stimuli as previously demonstrated in cultured adult EPDCs48. Current knowledge suggests that epicardial cells undergo EMT, forming EPDCs, which subsequently differentiate into other cardiac cell types3,4, ...
This finding could also be explained by the fact that vitamin D supplementation prevents acute respiratory infections (e.g., COVID-19) when given as low-dose daily maintenance, but not as high-dose intermittent bolus [185,186]. The potential role of vitamin D on vaccine responses seems ...
PD-1/PD-L1 inhibitors are becoming firmly established in the oncologist’s armoury and are likely to be one of the first of a new wave of drugs that successfully tackle cancers by exploiting the power of the immune system. Conflict of interest statement The authors declare that they have no...
(Methods section). This functional ageing signature shows a high concordance with previously reported ageing-associated transcriptional changes in individual species and tissues: we find an induction of the immune system, indicative of the low-grade inflammation in the elderly30, downregulation of cell ...