REFERENCES: Bluher M, Kahn BB, Kahn CR. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 2003 Jan 24;299(5606):572-4 Holzenberger M, Dupont J, Ducos B, Leneuve P, Geloen A, Even PC, Cervera P, Le Bouc Y. IGF-1 receptor regulates lifespan and res...
LongevityPrimary or secondary IGF1 deficiency has been implicated in shortening of lifespan. This paper reviews available data on the influence of IGF1 deficiency on lifespan and longevity in animals and man. It has been shown that inactivation of the IGF1 gene or of the GH receptor in both...
Receptor, InsulinRiskLongevityHormones, like insulin and insulin-like growth factor 1 (IGF-1), are thought to be deeply involved with longevity. Lower species have been the source for most of our current knowledge on the role of the insulin/IGF-1 signaling in modulating lifespan. This ...
Both have similar biological effects that are caused by binding to the IGF-1 receptor (IGF-1R), whereas the IGF-2R is specific for IGF-2 and thought to have no physiological role except serving to degrade IGF-228 (Figure 1). Serum concentrations of IGF-2 increase during childhood and ...
Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity in diverse model organisms. More recently, specific inhibition of mTORC1 to treat aging-related conditions has become the goal...
Lower IGF-1 signaling due to mutations with reduced activity of the IGF-1 receptor are associated with longevity and lower incidence rates of cancer[119]. Moreover, congenital IGF-1 deficiency has been shown to confer protection against the development of malignancies in humans including a lower ...
Germline Signaling Mediates the Synergistically Prolonged Longevity Produced by Double Mutations in daf-2 and rsks-1 in C.elegans Inhibition of DAF-2 (insulin-like growth factor 1 [IGF-1] receptor) or RSKS-1 (S6K), key molecules in the insulin/IGF-1 signaling (IIS) and target of rapam....
Using the enrichment results of candidate genes, we detected some pathways involved in cell differentiation, proliferation, and female gonadal development that may cause differences in egg production. Examples of these pathways were the PI3K-Akt signaling pathway (IGF2, COMP, and FGFR4), animal ...
10, 11, 12 Additionally, a significant difference was preliminarily proven in IGF-1 gene-expression levels, IGF-1 gene stabilities, and protein-binding affinity, with its receptor between AA and GG genotypes by Cheng et al.7,8. However, the studies of Cheng et al.7,8 were also only ...
Insulin-like growth factor-1 receptor (IGF-1R) polymorphic alleles and use of the same to identify DNA markers for reproductive longevity Disclosed herein are embodiments for genotyping an animal for the presence of polymorphic alleles in the IGF-1R gene that are associated with reproductive longevit...