Its master clock is located in the suprachiasmatic nucleus (SCN) of the hypothalamus, which can process light input signals and transmit timing information to other parts of the body [1]. Peripheral clocks are located in other tissues and organs, some are strictly dependent on the regulation of...
Alterations in metabolism, sleep patterns, body composition and hormone status are all key features of aging. While the hypothalamus is a well-conserved brain region that controls these homeostatic and survival-related behaviors, little is known about th
In a 2013 Nature paper, Einstein researchers made the surprising finding that the hypothalamus also regulates aging throughout the body. Now, the scientists have pinpointed the cells in the hypothalamus that control aging: a tiny population of adult neural stem cells, which were known to be ...
Leptin regulates food intake and energy reserves by controlling NPY/AgRP and POMC by binding to the leptin receptor in the hypothalamus [128]. However, leptin expression is found to be elevated in HFD-fed mice compared to that in chow-fed mice, which allows the use of pathologically increased...
Interrelationships between the hypothalamus, pituitary gland, ovary, adrenal gland, and the open period for LH release in the hen (Gallus domesticus) The asynchronous ovulatory cycle of the hen is believed to be the consequence of two interacting systems, one of which is circadian and regulates th...
AST effectively regulates and inhibits Aβ25–35-mediated oxidative stress–induced apoptosis of hippocampal neurons in AD mice through the SIRT1/PGC-1α signaling pathway. AST plays a protective role in neurons and enhances learning, memory, and cognitive abilities. Additionally, AST curtails senesc...
Most of the body’s TRH is produced by nuclei of the hypothalamus, which is the key regulator of arousal, metabolism and energy level. Food intake, temperature, fluid, endocrine and reproductive functions, sleep and wakefulness, emotion, stress circadian rhythm, visceral function, reward and punis...
The hypothalamus plays a central role in monitoring and regulating systemic glucose metabolism. The brain is enriched with phospholipids containing poly-unsaturated fatty acids, which are biologically active in physiological regulation. Here, we show that intraperitoneal glucose injection induces changes in ...
Recently, it has become a consensus that systemic decreases in NAD+ are a critical trigger for age-associated functional decline in multiple tissues and organs. The hypothalamus, which contains several functionally distinct subregions called nuclei, func
These results indicate that 3kPZS modulates GnRH release, which is important for steroidogenesis and final sexual maturation. Mammalian neurosecretory cells in the hypothalamus display pulsatile activities [33], and ovulation is induced by a LH (one of the mammalian counter-parts of GTH) surge ...