文档标签: transcription factors human motif lovmar motifs 系统标签: transcription factors human motif lovmar motifs CorrectionTheHumanTranscriptionFactorsSamuelA.Lambert,ArttuJolma,LauraF.Campitelli,PratyushK.Das,YimengYin,MihaiAlbu,XiaotingChen,JussiTaipale,*TimothyR.Hughes,*andMatthewT.Weirauch**Corresponde...
Leading EdgeReviewThe Human Transcription FactorsSamuel A. Lambert, 1,9 Arttu Jolma, 2,9 Laura F. Campitelli, 1,9 Pratyush K. Das, 3 Yimeng Yin, 4 Mihai Albu, 2 Xiaoting Chen, 5Jussi Taipale, 3,4,6, * Timothy R. Hughes, 1,2, * and Matthew T. Weirauch 5,7,8, *1 Department...
Benchmark and integration of resources for the estimation of human transcription factor activities. Genome Res. 29, 1363–1375 (2019). Article CAS PubMed PubMed Central Google Scholar Liu, Z.-P., Wu, C., Miao, H. & Wu, H. RegNetwork: an integrated database of transcriptional and post...
In brief, coexpression modules were inferred by the “runGENIE3” function, and potential direct binding targets (regulons) of transcription factors were identified using the human motif database of 10 kb around the transcription start site (TSS) for RcisTarget. Then, regulon activity in cell ...
4. Fulton DL, Sundararajan S, Badis G, Hughes TR, Wasserman WW, Roach JC, Sladek R: TFCat: The Curated Catalog of Mouse and Human Transcription Factors. Genome Biol 2009, 10:R29. 5. Vaquerizas JM, Kummerfeld SK, Teichmann SA, Luscombe NM: A census of human transcription factors: ...
et al. The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res. 46, D794–D801 (2018). Article CAS PubMed Google Scholar Lambert, S. A. et al. The human transcription factors. Cell 172, 650–665 (2018). Article CAS PubMed Google Scholar Kulakovskiy, I....
TRANSPATH is an information system on gene-regulatory pathways, and an extension module to the TRANSFAC database system (Wingender et al., Nucleic Acids Res., 28, 316-319, 2000). It focuses on pathways involved in...
Additionally, the data revealed that recombinant human IL-11 (Rh IL-11) exerted a cytoprotective effect against a range of DTX concentrations, indicating a potential mechanism by which IL-11 confers a survival benefit to prostate cancer cells (Fig. 4E, F). Live/dead assays further corroborated...
Peptide and protein identification and quantification were conducted using Proteome Discoverer 2.2 (PD 2.2, Thermo Fisher Scientific) based on the human reference database UniProt (http://www.uniprot.org). Proteins with at least one unique peptide with 1% FDR at the peptide level were retained for...
FOXO3 is consistently annotated as a human longevity gene. However, functional variants and underlying mechanisms for the association remain unknown. Here, we perform resequencing of the FOXO3 locus and single-nucleotide variant (SNV) genotyping in three