HLA-II viral antigen CD4+ T cell immunopeptidome SARS-CoV-2 noncanonical protein immunity antigen processing and presentation Research topic(s) CP: Microbiology CP: Immunology Introduction Recent success with synthetic vaccines against viral diseases has demonstrated their promise for future use, but als...
The Human Leukocyte Antigen Class II Immunopeptidome of the SARS-CoV-2 Spike GlycoproteinimmunopeptidomicsHLA-IImass spectrometryMAPPsspike glycoproteincoronavirusimmune responsedendritic cellCOVID-19The precise elucidation of the antigen sequences for T-cell immunosurveillance greatly enhances our ability to ...
The adaptive immune response is a major determinant of the clinical outcome after SARS-CoV-2 infection and underpins vaccine efficacy. T cell responses develop early and correlate with protection but are relatively impaired in severe disease and are asso
Robust prediction of HLA class II epitopes by deep motif deconvolution of immunopeptidomes. Nat. Biotechnol. 37, 1283–1286 (2019). Article CAS PubMed Google Scholar Chen, B. et al. Predicting HLA class II antigen presentation through integrated deep learning. Nat. Biotechnol. 37, 1332–...
Cancer progression is continuously controlled by the immune system which can identify and destroy nascent tumor cells or inhibit metastatic spreading. However, the immune system and its deregulated activity in the tumor microenvironment can also promote
presenting cells (APCs), where they are processed and presented by HLA molecules to CTLs22,30. A notable example for comparing the T cell immunogenicity of peptide-based vaccines with mRNA vaccines targeting similar antigens is CoVac-132. This multi-peptide-based vaccine comprises six SARS-CoV...
SARS-CoV-2 is an RNA virus of ~100 nm in diameter and is the causative agent of the COVID-19 pandemic. The genome is a negative strand RNA of ~30 kb, giving rise to a positive copy of the template for RNA-dependent RNA polymerase (RDRP)-mediated transcription after cell entry [3]...
The group of Pouya Faridi recently described an elegant approach termed SAPrIm, which presents a mid-throughput platform. This platform utilizes a semi-automated platform harnessing a KingFisher robot to isolate immunopeptidomes via anti-HLA antibodies attached to highly porous magnetic microbeads and ...
Schellens IM, Hoof I, Meiring HD, Spijkers SN, Poelen MC, van Gaans-van den Brink JA, van der Poel K, Costa AI, van Els CA, van Baarle D et al (2015) Comprehensive analysis of the naturally processed peptide repertoire: differences between HLA-A and B in the immunopeptidome. ...
Characterising the HLA‐I immunopeptidome of plasma‐derived extracellular vesicles in patients with melanomadoi:10.1002/jex2.146Boyne, CaitlinCoote, AbigailSynowsky, SilviaNaden, AaronShirran, SallyPowis, Simon J.Journal of Extracellular Biology