These neurons are stimulated in response to sugar but not artificial sweeteners, and are activated by direct delivery of sugar to the gut. Using functional imaging we monitored activity of the gut–brain axis, and identified the vagal neurons activated by intestinal delivery of glucose. Next, we...
Guided by gut sensory cues, humans and animals prefer nutritive sugars over non-caloric sweeteners, but how the gut steers such preferences remains unknown. In the intestine, neuropod cells synapse with vagal neurons to convey sugar stimuli to the brain within seconds. Here, we found that cholecy...
sweet taste: Trpm5−/− ;Tas1r2−/−Tas1r3−/− 通过对不同队列的小鼠摄入糖水后进行c-Fos染色发现,孤立束的尾核(cNST)上有明显的双侧标记,作者考虑直接从胃直接注入糖,发现也能激活cNST,说明这一部分神经会选择性的“吃糖”,并且独立于味觉传导通路。 胃-肠轴通过迷走神经将信息传递到大脑, 当...
These neurons are stimulated in response to sugar but not artificial sweeteners, and are activated by direct delivery of sugar to the gut. Using functional imaging we monitored activity of the gut–brain axis, and identified the vagal neurons activated by intestinal delivery of glucose. Next, we...
Birds were fed 0.25 mol L -1 sucrose, 0.73 mol L -1 sucrose and 0.73 mol L -1 glucose in separate laboratory trials to determine the concentration of sugar in the excreta. The red lory was efficient at energy extraction, excreting less than 1% sucrose equivalent, irrespective of the initia...
the mechanisms underpinning such effects are only beginning to be resolved. Microbiota–gut peptide interactions are poised to be of great significance in the regulation of gut–brain signaling. Given the emerging role of the gut–brain axis in a variety of brain disorders, such as anxiety and ...
The gut microbiota produces a host of bioactive metabolites that can alter the body’s homeostatic state allowing it to react to stressful conditions in a more adaptive manner (Westfall and Pasinetti, 2019). Generally classified as gut-brain-axis mechanisms, some of these adaptations include immun...
There is increasing evidence showing that the dynamic changes in the gut microbiota can alter brain physiology and behavior. Cognition was originally thought to be regulated only by the central nervous system. However, it is now becoming clear that many
et al. The gut – brain axis mediates sugar preference. Nature https://doi.org/10.1038/s41586-020-2199-7 (2020). This study identifies a key subpopulation of neurons in the nucleus of the solitary tract that are involved in sugar preference. Article PubMed PubMed Central Google Scholar ...
In a striking display of trans-kingdom symbiosis, gut bacteria cooperate with their animal hosts to regulate the development and function of the immune, metabolic and nervous systems through dynamic bidirectional communication along the ‘gut–brain axis’. These processes may affect human health, as...