Pck1pro/N‐end degronprotein degradationGluconeogenesis, the reverse process of glycolysis, is a favorable mechanism at conditions of glucose deprivation. Pck1 is a rate-limiting gluconeogenic enzyme, where its deficiency or mutation contributes to serious clinical situations as neonatal hypoglycemia and ...
The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis Daqian Xu, Zheng Wang, Yan Xia, Fei Shao, Weiya Xia, Yongkun Wei, Xinjian Li, Xu Qian, Jong-Ho Lee, Linyong Du, Yanhua Zheng, Guishuai Lv, Jia-shiun Leu, Hongyang Wang, Dongming Xing, Tingbo...
Altered glucose metabolism endows tumor cells with metabolic flexibility for biosynthesis requirements. Phosphoenolpyruvate carboxykinase 1 (PCK1), a key enzyme in the gluconeogenesis pathway, is downregulated in hepatocellular carcinoma (HCC) and predic
The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis Nature, 580 (2020), pp. 530-535 CrossrefView in ScopusGoogle Scholar Yang and Lu, 2015 W. Yang, Z. Lu Pyruvate kinase M2 at a glance J. Cell Sci., 128 (2015), pp. 1655-1660 View in ScopusGoogle Scholar Yang and...
(reverse glycolysis). We therefore studied the role of PCK2 in ECs in more detail, revealing a role for PCK2 in proteostasis, independent of its gluconeogenic activity. Pertubation of this role likely contributed to the angiogenic defects observed in vivo and in vitro in ECs with reduced PC...
The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis. Nature. 2020;580:530–5. https://doi.org/10. 1038/s41586-020-2183-2. 53. Nelson ME, et al. Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and ...
A previous study initially found that gluconeogenic metabolizing enzyme PCK1 has protein kinase activity, which led to the discovery of the mechanism of tumor cell-specific lipid anabolism. PCK1 phosphorylates the endoplasmic reticulum transmembrane protein INSIG1/2 with GTP as a phosphate donor, ...
[42] using northern blotting and transcriptomic analyses showed that transcripts encoding the gluconeogenic enzymes (FBP1 and PCK1) are repressed by glu- cose in S. cerevisiae. Furthermore, previous work by Sandai et al. [35] reported that ICL1 and PCK1 are repressed by glucose in C. ...
The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis. Nature 580, 530–535 (2020). Article CAS PubMed Google Scholar Yang, W. et al. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell 150, 685–696 (2012). Article CAS PubMed PubMed ...
Crh proteins catalyze crosslinking of chitin and glucan polymers in fungal cell walls. Here, we show that the BcCrh1 protein from the phytopathogenic fungus Botrytis cinerea acts as a cytoplasmic effector and elicitor of plant defense. BcCrh1 is localize