J. The GH/IGF-1 axis in ageing and longevity. Nat. Rev. Endocrinol. 9, 366–376 (2013). Article CAS PubMed PubMed Central Google Scholar Desbuquois, B., Carré, N. & Burnol, A. F. Regulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/...
K. et al. The GH/IGF-1 axis in ageing and longevity. Nat. Rev. Endocrinol. 9, 366–376 (2013). Article CAS Google Scholar Pollak, M. The insulin and insulin-like growth factor receptor family in neoplasia: an update. Nat. Rev. Cancer 12, 159–169 (2012). Article CAS Google ...
The human growth hormone gene ( GH1 ) and the insulin-like growth factor 1 and 2 genes ( IGF1 and IGF2 ) encode the central elements of a key pathway infl... S Rodriguez,TR Gaunt,INM Day - 《Human Genetics》 被引量: 346发表: 2007年 The GH/IGF-1 axis in ageing and longevity Se...
Papaconstantinou J, Deford JH, Gerstner A, Hsieh C-C, Boylston WH, Guigneaux MM, Flurkey K, Harrison DE (2005) Hepatic gene and protein expression of primary components of the IGF-1 axis in long lived Snell dwarf mice. Mech Ageing Dev 126:692–704...
The GH/IGF-1 axis in ageing and longevity Nat. Rev. Endocrinol., 9 (2013), pp. 366-376, 10.1038/nrendo.2013.67 View in ScopusGoogle Scholar [23] S. Moran, Y. Chen, A. Ruthie, Y. Nir Alterations in IGF-I affect elderly: role of physical activity Eur. Rev. Aging Phys. Act., ...
Hutchinson–Gilford progeria syndrome (HGPS) is a rare, premature ageing syndrome in children. HGPS is normally caused by a mutation in the LMNA gene,
(3) inhibition of the GH/IGF1 axis and (4) drugs that activate AMPK or specific sirtuins (Longo et al.2015). In fact, all of the mentioned approaches are related to sirtuins. These enzymes are involved in mimicking dietary restriction, as it has been shown, for example, for resveratrol...
For example, stem cells use insulin-like growth factor 1 (IGF1) for repair and regeneration. Overexpression or elevated activity of such a growth factor is required to improve muscle regeneration [34]. The signaling events of growth hormone are required to control the proliferation and development...
Thyroid hormones have vital roles in development, growth and energy metabolism. Within the past two decades, disturbances in thyroid hormone action have been implicated in ageing and the development of age-related diseases. This Review will consider resu
Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity in diverse model organisms. More recently, specific inhibition of mTORC1 to treat aging-related conditions has become the goal...