aThe genotype of an individual is its specific genetic encoding; in the case of species that reproduce sexually,the genotype of an individual is entirely determined by that of its parents, each of whom contribute half of their own genotype to the offspring. 个体的基因型是它的specific基因...
Loisel DA, Tan Z, Tisler CJ, Evans MD, Gangnon RE, Jackson DJ, Gern JE, Lemanske RF Jr, Ober C (2011) IFNG genotype and sex interact to influence the risk of childhood asthma. J Allergy Clin Immunol 128:524–531. doi:10.1016/j.jaci.2011.06.016 Article PubMed CAS Google Scholar ...
The primers of mouse genotype identification are shown in Additional file 1: Table S26. Identification of tameness The tameness of mice was measured via the method described in Nagayama et al. [57] with some modifications. Tameness has two behavioral components: active tameness and passive ...
Late-onset Alzheimer’s disease (AD) can, in part, be considered a metabolic disease. Besides age, female sex andAPOEε4 genotype represent strong risk factors for AD that also give rise to large metabolic differences. We systematically investigated group-specific metabolic alterations by conducting...
We model the expression data as having a log normal distribution with a log standard deviation of 0.13 within each genotype class (AA, AB, BB). This level of noise is based on estimates from initial GTEx data. The effect size depends both on the minor allele frequency of the SNP (MAF)...
also found in higher levels in the cerebrospinal fluid of MSA patients and correlated with a greater distribution of AA genotype compared to healthy controls [185]. This genotype also manifested phenotypically with earlier onset of symptoms and greater progression of disease compared to non-AA ...
Multi-sample SNP/genotype calling was carried out using the algorithm implemented in Samtools v1.3 for each species independently, requiring minimum base and mapping qualities of 20. Species VCF files were then merged and genotypes filtered using a minimum site quality (QUAL) of 20, RMS minimum ...
Individuals with TT and AT genotypes had higher ASIP mRNA levels in the skin than did those with the AA genotype (PT mutation might shift the promoter binding affinity with differential transcription factors. In summary, we identified a novel mutation in the ASIP gene promoter that may affect ...
Using the information above, we calculated the posterior probability of each genotype using a Bayesian formula. The genotype of each position was assigned as the allele type that had the highest probability. A rank sum test was applied to adjust for the probability of heterozygotes. The final co...
genotype calls occurring at the point of misjoin. Chimeric scaffolds were split, and their components were remapped. Thus, approximate chromosomal placements were obtained for 1,692 and 459 genetically verified scaffolds, respectively. Conventional molecular marker maps (Supplementary Data Set 2) and ...