Telomeres are specialized nucleoprotein structures found at the ends of linear chromosomes that guard against aberrant chromosomal rearrangements and prevent the ends of DNA molecules from being...doi:10.1007/978-1-59745-221-2_7Jay E. Johnson
5. What is the function of applied research on how to communicate science online? A. To diversify the ways of communicating science. B. To help the public correctly understand science. C. To promote the development of social media. D. To control online communication systems. 6. What do the...
The main function of telomerase is to synthesize telomeres, which can maintain a stable length due to the existence of telomerase [29, 30]. Fig. 3: The vertebrate telomerase complex. The composition of human telomerase is divided into three parts: TERT, TEN, and Cofactor. They combine ...
Noun1.telomere- either (free) end of a eukaryotic chromosome; "telomeres act as caps to keep the sticky ends of chromosomes from randomly clumping together" chromosome- a threadlike strand of DNA in the cell nucleus that carries the genes in a linear order; "humans have 22 chromosome pairs...
The non-canonical biological function of TERT and its influence on different components of the tumor microenvironment in cancer cells, including angiogenesis, vascularization, EMT, proliferation, inflammatory factors, and immune response, are influenced by TERT. ...
.Therapiestargetingtelomere-telomerasesystem,telomerasereversetranscriptasetransfectionandalterativetelomerelengtheningmustbeidentifiedbeforegenetherapycancommence.Keywords:diabetesmellitus,diabeticvascularcomplication,oxidativestress,telomere-telomerasesystemExpertOpin.Ther.Targets[EarlyOnline]1.IntroductionTelomeresareDNA-protein...
Still more likely is the involvement of the polycomb group gene Bmi-1. Bmi-1 has been shown to play a key role in maintaining indefinite self-renewal of normal stem and cancer stem cells, a function which must necessarily be linked to maintenance of telomeres in stem cells (discussed below...
Homologues of human TRF have been found in the genomes of T. brucei, T. cruzi and L. major based on sequence similarities to the C-terminal Myb-like DNA binding domain. For example, the T. brucei TRF2 homologue known as TbTRF shares a similar telomere end-protection function with ...
Moreover, it was found that the Gm02 upstream telomere produced by Canu (8449 bp) was obviously longer than that of Hifiasm (3045 bp), so that we updated it. The precise locations of telomeres within the ZH13-T2T genome were ascertained by using seqtk (https://github.com/lh3/seqtk). ...
It is therefore believed that telomeres are part of a mechanism to detect the number of cell replications and DNA damage with the function of preventing uncon- trolled cell proliferation, the main hallmark of cancer (Wright and Shay, 2005; Aubert and Lansdorp, 2008). On the other hand, ...