The Structure and Function of Telomerase Reverse Transcriptase. The structure and integrity of telomeres are essential for genome stability. Telomere dysregulation can lead to cell death, cell senescence, or abnormal ce... Autexier,Chantal,Lue,... - 《Annual Review of Biochemistry》 被引量: 571发...
Telomeres are specialized nucleoprotein structures found at the ends of linear chromosomes that guard against aberrant chromosomal rearrangements and prevent the ends of DNA molecules from being...doi:10.1007/978-1-59745-221-2_7Jay E. Johnson
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biologicalfunctions:maintainingthestabilityofchromosomes;preventingtheend fusionofchromosomes;protectingchromosomestructure;anddeterminingthe lifespanofcells.BecausetheshorteningoftelomeresoccursduringDNAreplication andcelldivision,thetelomerelengthisconsideredtobethelife-clockofthecell. ...
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Still more likely is the involvement of the polycomb group gene Bmi-1. Bmi-1 has been shown to play a key role in maintaining indefinite self-renewal of normal stem and cancer stem cells, a function which must necessarily be linked to maintenance of telomeres in stem cells (discussed below...
1.2.3. Function HMGB1 plays a key role in both acute and chronic inflammation. In physiological conditions, this protein is inside the nucleus of quiescent macrophages/monocytes. Cell stress or death are the main mechanisms that lead to the release of HMGB1 outside the cell membrane, thus HMGB1...
Additionally, BC patients with a short allele (S) within VNTR-MNS16A showed higher expression of the SP1 and had longer telomeres. Our results provide more information on the regulation of TERT in terms of mRNA expression as well as the genetic variability of TERT and telomere length in ...
In the sixth edition of the World Health Organization manual for the examination and processing of human semen, extended examination methods to provide key diagnostics in the investigation of the male reproductive system function are elaborated. These go beyond the basic analysis of semen and may be...
H. Structure and function of telomeres. Nature 350, 569–573 (1991). CAS PubMed Google Scholar Jaskelioff, M. et al. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature 469, 102–106 (2011). CAS PubMed Google Scholar Ourliac-Garnier, I. & ...