A study was undertaken to confirm the Valtis and Kennedy salt effect (decrease in affinity of hemoglobin for oxygen with neutral salts) and to propose an explanation of the chemical mechanisms operating. Several concentrations of various neutral salts were added to whole blood which was depleted ...
Adaptations for Oxygen Transport: Lessons from Fish Hemoglobins Hemoglobin (Hb) is a prototype of macromolecules whose functional properties are controlled by ionic effectors and a paradigm for study of the structure, function and allosteric interactions of proteins. By virtue of its well-defined rol...
An iron-containing protein in the blood of many animals that, in vertebrates, carries oxygen from the lungs to the tissues of the body and carries carbon dioxide from the tissues to the lungs. Hemoglobin is contained in the red blood cells of vertebrates and gives these cells their characteris...
While anemia is associated with poor functional and mortality outcomes in the elderly, the impact of hemoglobin decline is less studied. We evaluated the determinants and consequences of hemoglobin decline in 3,758 non-anemic participants from the Cardiovascular Health Study, a prospective cohort of ...
Related to hemoglobin:Hemoglobin A1c he·mo·glo·bin (hē′mə-glō′bĭn) n. The protein in the red blood cells of vertebrates that carries oxygen from the lungs to tissues and that consists of four polypeptide subunits, each of which is bound to an iron-containing heme molecule. ...
4 Disease is the unhealthy state of a body part, a physiologic system, or the body as a whole; there is a disordered structure or function. Disease often begins at the cellular level. An abnormal gene, acquired through one’s ...
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The sequences are compared with human hemoglobin. Amino-acid replacements at positions critical for structure and function of the hemoglobin are discussed. The requirements for binding of ATP and also of DPG as allosteric effectors at the beta-chains seem to be fulfilled. Comparison of the alpha-...
A novel hemoglobin variant was observed in pure sheep ( Ovis aries) breeds of the island of Chios (Greece), Egypt and Hungary. This silent variant was identified by gel electrophoresis and RP-HPLC of dissociated globin chains. Two Arg for Lys substitutions were detected, by means of MALDI TO...