1. Eosinophilia has been produced experimentally in guinea pigs by the injection of extracts of Ascaris suum and histamine, the accompanying histologic changes, particularly the distribution of eosinophils, being noted.2. The tissues of guinea pigs suffering from a natural eosinophilia have been ...
Eosinophils are found throughout evolution and there is a clear co-evolution with the presence of helminths in the host [1]. Despite this general finding the actual function of eosinophils is yet to be established [2]. The long-lasting hypothesis of eosinophils as effector cells in defence ag...
Reports that an accumulation of eosinophils occurs approximately 24 hours after the application, in pollens-sensitive patients, of pollen extract to the superficially denuded skin were confirmed. The response was seen in patients having clinical sensitivity to grass and ragweed pollen and was absent in...
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Like basophils and eosinophils, neutrophils and their function have been underestimated in research for a long time. Thus, neutrophils have been categorized as short-lived phagocytic cells of the innate immune system with limited ability for biosynthetic activity and being the first cells appearing in...
The infiltration and functional regulation of eosinophils induced by TSLP promote the proliferation of cervical cancer cell. Cancer Lett. 364, 106–117 (2015). Article PubMed CAS Google Scholar Cipolat, S., Hoste, E., Natsuga, K., Quist, S. R. & Watt, F. M. Epidermal barrier ...
Inflammatory responses and impaired mitochondrial function have been implicated in the function of many organs, and many of these effects are detrimental. Recently, investigations on the cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) synthase (cGAS)-stimulator of interferon genes (STING) pa...
The aim of this study is to investigate the clinical value and potential prognostic significance of lung function assessment and Testin expression in non-small cell lung cancer (NSCLC) patients. Methods The NSCLC patients were classified into three groups according to lung function: group of normal...
3. Role of activin-A in the regulation of innate and adaptive immune responses 4. The function of activin-A in microbial host defense 5. Activin-A in the regulation of allergic diseases 6. Activin-A effects on the pathogenesis of autoimmune disorders 7. Divergent effects of activin-A on ca...
It is important to improve our understanding of the presence and function of eosinophils within different tumor types, the role of heterogeneous stromal microenvironments in driving eosinophil responses, and whether systemic eosinophil suppression with anti–IL-5 agents alters long-term cancer risk. Curr...