However, the function of CX3CL1 in clear cell renal cell carcinoma (ccRCC) remains poorly defined.The pan-cancer expression pattern and prognostic value of CX3CL1 were evaluated in this study. Moreover, the relationship of CX3CL1 expression with the tumor microenvironment, especially the tumor...
CX3CR1 is expressed on monocytes, natural killer cells, T cells, and smooth muscle cells, where it mediates migration, adhe- sion and proliferation[20]. Promotion of cell survival is consid- ered another key function of CX3CL1 operating under both homeostatic and inflammatory conditions[20]....
CX3CL1 (fractalkine) is the only member of the CX3C (delta) subfamily of chemokines which is unique and combines the properties of both chemoattractant and adhesion molecules. The two-form ligand can exist either in a soluble form, like all other chemokines, and as a membrane-anchored molecu...
Our findings suggest a mechanism by which macrophages amplify and promote CX3CR1+ cell accumulation within the lungs during both acute and chronic inflammatory stress. We suggest that one function of the CX3CR1-CX3CL1 pathway is to recruit and sustain divergent immune cell populations implicated...
This study shows that spinal nerve injury, but not peripheral inflammation, induces the expression of a chemokine, CX3CL1 (fractalkine), in astrocytes and upregulates CX3CR1 in microglia in the spinal cord. This selective regulation of CX3CL1 and its receptor, CX3CR1, suggests that these ...
in preclinical and clinical development include adoptive transfer therapies, direct stimulation, recruitment of NK cells into the tumor microenvironment (TME), blockade of inhibitory receptors that limit NK cell functions, and therapeutic modulation of the TME to enhance antitumor NK cell function. In...
CX3CL1 is a chemoattractant and adhesion molecule that induces the redistribution of CX3CR1-positive inflammatory leucocytes to sites of inflammation. As a consequence of their increased expression in plaques of psoriasis, and location within genomic regions previously linked to this disease, CX3CL1...
Partial experiment result was confirmed by following Western blotting.【Conclusions】 Based on our results, we conclude that the overexpression of RIPK3 could modulate the expression of CX3CL1 in SH- SY5 Y at m RNA and protein levels,and play an important role in a variety of physiological ...
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reported that FKN microinjection pro- duces cardiovascular response in the NTS of normal rats [13]. However, the function of CX3CR1 during neuro- genic hypertension progression in the NTS is ambigu- ous. On the other hand, NO is a gas molecule that is involved in various functions in ...