In T. maritima, an [FeFe] hydrogenase has been shown to catalyze the reduction of H+ to H2 using glycolytic products NADH and reduced ferredoxin (Fd) as electron donors (Fig. 5B) (Schut and Adams, 2009). The activity of this enzyme depends on FMN, and this enzyme is thought to have...
The function of EVs during physiological and pathological processes depends on the load of EVs and their ability to interact with receptor cells to deliver proteins, lipids, and RNAs. EVs bind to target cells specifically, and these bindings depend on the EV contents (including proteins, miRNAs,...
To probe the contribution of these cells to behavior, we developed optogenetics for the gut lumen by engineering a flexible fiberoptic. We showed that preference for sugar over sweetener in mice depends on neuropod cell glutamatergic signaling. By swiftly discerning the precise identity of nutrient ...
To regulate their social behaviors,M. xanthuscells occasionally reverse their direction of movement36. The Frz chemosensory system induces these reversals36and acts on the polarity module to induce an inversion of its polarity33,37, thereby laying the foundation for activating the motility machineries ...
PROBLEM TO BE SOLVED: To obtain a S-cyanohydrin useful as a synthetic raw material, etc., by stirring an aldehyde or a ketone solution, an aqueous solution of a (S)- hydroxynitrile-lyase and a cyanide group-donor, carrying out a reaction in an emulsified state and then separating the ...
Importantly, the catalytic function of ALKBH1 with various substrates is related to various human disorders. Despite efforts, there continues to be disagreement concerning ALKBH1's enzymatic activity towards various substrates. In this review, we elaborate on the most recent developments in the ...
This enzyme is inhibited when the concentration of isoleucine reaches a sufficiently high level. Isoleucine binds to a regulatory site on the enzyme, which is distinct from its catalytic site. The inhibition of threonine deasminase is mediated by an allosteric interaction, which is reversible. When...
and the ability to function in synergy with multiple components. Compared to traditional synthesized small-molecule drugs, natural drugs also have the advantages of abundant resources, low cost, and easy availability, making them an important source of new drug development. More than half of the ne...
Centromeres are unique chromosomal domains that control chromosome segregation, and are epigenetically specified by the presence of the CENP-A containing nucleosomes. CENP-A governs centromere function by recruiting the constitutive centromere associated
Even after successful extinction, conditioned fear can return. Strengthening the consolidation of the fear-inhibitory safety memory formed during extinction is one way to counteract return of fear. In a previous study, we found that post-extinction L-DOP