The design of proteins that bind to a specific site on the surface of a target protein using no information other than the three-dimensional structure of the target remains a challenge1–5. Here we describe a general solution to this problem that starts
The third group comprises unique, single-copy DNA sequences, which do not share homology with any other sequences in the genome. Examples of such sequences in the human genome include protein-coding genes (e.g., theglobin,ovalbumin, andsilk fibroingenes), non-coding RNAs, and regulatory ele...
Light-harvesting complexes (LHCs) are pigment-protein complexes whose main function is to capture sunlight and transfer the energy to reaction centers of photosystems. In response to varying light conditions, LH complexes also play photoregulation and photoprotection roles. In algae and mosses, a su...
To establish a spatial single-cell landscape in pan-cancer, we acquired scRNA-seq data from 69 samples of 56 patients diagnosed with one of the six prevalent cancer types, along with ST data from 22 tissue slices of 22 patients (Fig.1a and b; Table S1and S2). Among them, the ST data...
(e-value < 1.00E-07) to other sequences in publicly available nucleotide or protein databases. Unknown genes, such as Contig 4863-1 and 5300-1, were up-regulated at 3-, 7- and 14-dpe, while the singlet ES728532 showed down-regulation at all regeneration stages. On the other hand, ...
The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) is a complex ecosystem that drives tumor progression; however, in-depth single cell characterization of the PDAC TME and its role in response to therapy is lacking. Here, we perform single-cell RNA sequencing on freshly ...
The field of Membrane Protein Structural Biology has grown significantly since its first landmark in 1985 with the first three-dimensional atomic resolution structure of a membrane protein. Nearly twenty-six years later, the crystal structure of the beta2 adrenergic receptor in complex with G protein...
Altogether, these data suggest an emergence of an animal-like ECM structure in the ancestor of Pluriformea, filastereans, choanoflagellates, and metazoans after its divergence from ichthyosporeans. Focal adhesion kinase (FAK) is a cytoplasmic (non-receptor) protein tyrosine kinase that functions ...
of serotonin (5-hydroxytryptamine), 5-hydroxytryptamine-N-acetyltransferase (SNAT) and n-acetyl-5-hydroxytryptamine-methyltransferase (ASMT)/caffeic acid-o-methyltransferase (COMT), catalyzing the final formation of melatonin from serotonin. Studies have found that there are at least four possible ...
Generalization is central to motor learning. However, few studies are on the learning generalization of BCI-actuated supernumerary robotic finger (BCI-SRF) for human-machine interaction training, and no studies have explored its longitudinal neuroplastic