Main molecular pathways activated in the presence or absence of nutrients. (a) The synergic import of leucine (Leu) and glutamine (Gln) (top left) results in mTORC1 recruitment to the lysosomal membrane and its subsequent activation by at least two distinct pathways. The first one proposes tha...
Glycolysis | Pathway, Steps & Products from Chapter 7/ Lesson 2 229K Understand the process of glycolysis and learn the steps involved. Identify the products of glycolysis. Related to this Question What is accomplished in the payoff phase of glycolysis?
Women are born with all of their oocytes. The oocyte proteome must be maintained with minimal damage throughout the woman’s reproductive life, and hence for decades. Here we report that oocyte and ovarian proteostasis involves extreme protein longevity. Mouse ovaries had more extremely long-lived...
superoxide and ROS can potentially impede the activity of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), which is a fundamental component of glycolysis and is responsible for converting glyceraldehyde-3-phosphate into 1,3-biophosphoglycerate
AGE generation is intricate and involves the Maillard reaction, the polyol pathway, the Namiki pathway, the Wolff pathway, the Hodge pathway, glycolysis and ketone body metabolism (Khalid et al.2022). The classic and predominant pathway among these pathways is the Maillard reaction, which can be...
Adaptation to alkalinization of the medium in fungi involves an extensive remodeling of gene expression. Komagataella phaffii is an ascomycetous yeast that has become an organism widely used for heterologous protein expression. We explore here the transc
Briefly, log-normalization, scaling, cell cycle phase assignment and regression, clustering and differentially expressed gene (DEG) analysis were implemented. In order to reduce background noise, the log-normalized data were reduced to the first 2,000 most highly variable genes. After scaling, ...
For the first time, we unveil the anti-proliferative properties of the L. lactis cell-free supernatant (CFS), which are independent of bacteriocins or other small molecules. We demonstrate that ADI, derived from a dairy-Generally Recognized As Safe (GRAS) strain of L. lactis, exhibits anti-...
AMPK suppresses mTOR activity via two distinct pathways. The first involves the tuberous sclerosis complex 2 (TSC2). AMPK can activate TSC2, a GTPase-activating protein that teams up with TSC1, inhibiting the RAS homolog enriched in the brain (Rheb) and mTOR, ultimately preventing mTORC1 activ...
regulation of timing of transition from vegetative to reproductive phase; regulation of lipid metabolic process; organic cyclic compound catabolic process; regulation of response to stress; negative regulation of cellular protein metabolic process; positive regulation of developmental process; glycogen metabolic...