With the popularization and application of PARP inhibitors in the clinic, especially in the treatment of ovarian cancer, the problem of drug resistance has limited its use troubling all oncologists. To overcome its resistance and improve its effect, more and more studies have been carried out in...
ATP-binding cassette sub-family G member 2 JAK/STAT: Janus kinase /signal transducer and activator of transcription TCA: Tricarboxylic acid cycle OXPHOS: Oxidative phosphorylation PDK: Pyruvate dehydrogenase kinase CRC: Colorectal cancer RNAi: RNA interference PFKFB4: 6-Phosphofructo-2-kinase...
Targeted protein degraders crowd into the clinic. Nat. Rev. Drug Discov. 20, 247–250 (2021). CAS PubMed Google Scholar Wu, T. et al. Targeted protein degradation as a powerful research tool in basic biology and drug target discovery. Nat. Struct. Mol. Biol. 27, 605–614 (2020). ...
Besides, such drugs could not prevent, halt or reverse the progression of this complicated disease. Therefore, therapies or drugs which can intervene the development of gout are greatly needed in clinic. Traditional Chinese medicine (TCM) has been applied to treat gout since the ancient China [...
There are still several obstacles in the way to find a successful translation of RNA-based therapeutics into a clinic. One of the biggest challenges is specificity. Candidate RNA therapeutics may cause off-target effects in a sequence-dependent and sequence-independent manner, and these include part...
Interlinked and fundamental aging processes appear to be a root-cause contributor to many disorders and diseases. One such process is cellular senescence, which entails a state of cell cycle arrest in response to damaging stimuli. Senescent cells can ari
The Guangdong-Hong Kong-Macao Greater-Bay-Area of South China has an 86 million population and faces a significant challenge of Alzheimer’s disease (AD). However, the characteristics and prevalence of AD in this area are still unclear due to the ra
of wider health concerns beyond bone health [12,13], the impact of other manifestations of OI on HRQoL, and the impact of OI on affected family members caring for affected individuals and other family members, especially non-affected siblings. Only few studies have examined facets of the socio...
Specificity of the multi-target stool DNA test for colorectal cancer screening in average-risk 45-49 year-olds: a cross-sectional study. Cancer Prev Res (Phila). 2021;14(4):489-496. doi:10.1158/1940-6207.CAPR-20-0294PubMedGoogle ScholarCrossref 12. Leeflang MM, Bossuyt PM,...
First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece 10 Obstetric and Gynecologic Clinic, Medical School, Democritus University of Thrace, 68110 Alexandroupolis, Greece add Show full affiliation list * Author to whom correspondence should be...