Is aging, as most people think, a fundamental, totally unalterable, fact of life? Or is aging actually similar to a universal, but potentially highly treatable, genetic disease? Darwin's dilemma, a little known quirk of the theory of evolution, has for more than 140 years led scientists ...
Citation:Fabian, D. & Flatt, T.(2011)The Evolution of Aging.Nature Education Knowledge3(10):9 AaAaAa Aging is an Evolutionary Paradox Why do we age and die? Aging, orsenescenceas it is sometimes called, is an inevitable progressive deterioration of physiological function with increasing age,...
Between the 1930s and 50s, evolutionary biologists developed a successful theory of why organisms age, firmly rooted in population genetic principles. By the 1980s the evolution of aging had a secure experimental basis. Since the force of selection declines with age, aging evolves due to mutation...
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Evolutionary explanations of aging (or senescence) fall into two classes. First, organisms might have evolved the optimal life history, in which survival a
The evolutionary stages of development of various forms of aging (molecular, segregational, conditional, clonal, postmitotic, and systemic) are established. 关键词: fractal aging evolution DOI: 10.1134/S207905701102010X 被引量: 6 年份: 2011 ...
Aging is here defined as inherent, progressive, irreversible impairments of function. It occurs not only in higher organisms but also as far down the scale of beings as some — but not all — unicellular organisms. What does the whole array of organisms tell us about aging? Is there a good...
Evolution in health and medicine Sackler colloquium: Evolution of the human lifespan and diseases of aging: roles of infection, inflammation, and nutrition ... E Caleb,Finch - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 361发表: 2010年 Evolution...
Horizons in the evolution of aging. BMC Biol. 16, 93 (2018). PubMed PubMed Central Google Scholar Rokas, A. The origins of multicellularity and the early history of the genetic toolkit for animal development. Annu. Rev. Genet. 42, 235–251 (2008). CAS PubMed Google Scholar ...
According to the classic theory of life history evolution, ageing evolves because selection on traits necessarily weakens throughout reproductive life. But this inexorable decline of the selection force with adult age was shown to crucially depend on specific assumptions that are not necessarily fulfilled...