the localization ofCNR1in Leydig cells and gonocytes indicate both these cell types could be sensitive to 2-AG, a highly effective agonist of CB1 [53] mainly synthesized by fetal Leydig cells. This uncovers a potential new autocrine and paracrine signaling pathways...
Glioblastoma (GBM) is the most common and lethal primary brain tumor, presenting an overall median survival of under 15 months with current treatments (surgical resection, radiotherapy (RT) and temozolomide (TMZ) chemotherapy) [6]. While the incidence of central nervous system (CNS) tumors is lo...
to access the circulatory system via the paracellular pathway [86]. Despite our current limited understanding of the mechanisms underlying EVs traversal of the BRB, it is plausible to speculate that they can traverse both from the retina to the blood and vice versa, mainly through transcytosis in...
The largest region of the brain that governs all higher functions (memory, reasoning, and some aspects of personality) consists of two hemispheres connected by the corpus callosum is called: a. Cerebellum b. Medulla oblongata c. Cerebrum ...
The somatic endocrine cells of the ovarian follicle - the granulosa cells (GCs)—participate in the strict hypothalamic-pituitary-ovarian (HPO) feedback loop that governs the menstrual cycle via endocrine and paracrine regulators, as AMH and Inhibins. We aimed to unravel the direct effect of the...
Table 1 Comparisons among various microfluidic chips designed for different parts of the female reproductive system Full size table Fig. 1 Schematic diagram of the microfluidic chip in the female reproductive system. It mainly includes microfluidic chips for the ovary, uterus, fallopian tube, placenta...
Different transcripts encoding distinct receptor isoforms (CB1, CB1A, CB1B and CB2A) were also differentially distributed, mainly in germ cells. The cannabinoid-metabolising enzymes were abundantly present; the α/β-hydrolase domain-containing protein 2 (ABHD2) in all germ cell types, except ...
Structurally, STAT3 mainly consists of the N-terminal domain (NTD), coiled-coiled domain, DNA binding domain (DBD), linker domain, Src homology 2 (SH2) domain and transactivation domain (TAD) [2]. The tyrosine residues 705 and serine residues 727 located in the C-terminal are considered tw...
Environmental factors that strongly affect the performance of nanobiochar in environmental remediation mainly include pH, coexisting ions, dissolved organic matter (DOM), organisms and root exudates (soil system) (see details in Fig. 5). Environment pH strongly governs the biogeochemical behavior of na...
Studies of LHRH Secretion into the Hypophyseal Portal Blood of the Ram: Gonadal Regulation of LH Secretion Is Exerted Mainly at the Hypothalamic LevelLHRH is the most important peptide involved in the regulation of reproduction, and the pattern of LHRH secretion is the major control that governs,...