The ionic radii of the ions S2-, Cl-, and K+ are 184, 181, 138 pm respectively. Explain why these ions have different sizes even though they contain the same number of electrons. Unlike elements in groups 1A-3A, which can form cations, and atoms i...
VEGFR2 (KDR/Flk1) signaling in endothelial cells (ECs) plays a central role in angiogenesis. The P-type ATPase transporter ATP7A regulates copper homeostasis, and its role in VEGFR2 signaling and angiogenesis is entirely unknown. Here, we describe the un
PhoPV_DBD, PhoPVI_DBD located at the upstream double-stranded DNA.b, The relative locations between PhoPI_DBD and PhoPII_DBD bound to the promoter DNA. The secondary structural elements involved in PhoPI_DBD and PhoPII_DBD are labeled, respectively.cDetailed interactions betweenMtbPhoPI_DBD, ...
Nd was separated from rare earth elements using columns coated with di (2-ethylhexyl) orthophosphoric acid. The analytical procedures for Sr–Nd–Pb isotopes have been described in detail by Jiang et al. (1999). Sample solutions in 2% HNO3 were introduced through a soluble polytetrafluoroethylene...
Understanding the mechanistic effects of novel immunotherapy agents is critical to improving their successful clinical translation. These effects need to be studied in preclinical models that maintain the heterogenous tumor microenvironment (TME) and dys
Fluorine, as one of the most reactive and electronegative of all elements, is a powerful ligand for metal transport (including U and REE) in hydrothermal systems (Seward and Barnes, 1997, Wood and Samson, 1998). However, there are relatively few settings where F is sufficiently abundant to ...
Somatic embryogenesis is a major process for plant regeneration. However, cell communication and the gene regulatory network responsible for cell reprogramming during somatic embryogenesis are still largely unclear. Recent advances in single-cell technol
which form a transcription complex that recognizes E-box-like hypoxia response elements and initiates the transcription of genes involved not only in cellular oxygen homeostasis but also in pathways that coordinate cell proliferation, metabolism reprogramming, apoptosis, or resistance to tumor therapy [135...
These observations suggest that phenotypically distinct fibroblasts exist in polyps and tumors, and thus may play a role in tumorigenesis in precancerous lesions. We next integrated our scATAC-seq and snRNA-seq datasets to enable analyses of regulatory elements and TFs potentially driving gene ...
Transposable elements (TEs) are prevalent repeats in the human genome, play a significant role in the regulome, and their disruption can contribute to tumorigenesis. However, TE influence on gene expression in cancer remains unclear. Here, we analyze 275 normal colon and 276 colorectal cancer sampl...