Using DNA-PAINT super-resolution microscopy, we find that most BCRs are present as monomers, dimers, or loosely associated clusters on resting B cells, with a nearest-neighbor inter-Fab distance of 20–30 nm. We leverage a Holliday junction nanoscaffold to engineer monodisperse model antigens...
Only the distance distribution of the 1/8 dimer model gives a satisfactory fit as judged by the 4/5 weighted residuals and dimer: 0.59; 5/6 dimer: t0h.7e3r.e(dbu)cTehdechscihseqmuaarteicdpχrre2s.eFnittarteisounltsshoofwTsGthRe5tYw1o1i1nAdifvoirduxDalimaepr:p1a/r8endtimdiesrt:...
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"Mind the Gap": The Size-Distance Dissociation in Visual Neglect is a Cueing Effect 来自 国家科技图书文献中心 喜欢 0 阅读量: 30 作者:RD Mcintosh,KI Mcclements,HC Dijkerman,AD Milner 摘要: There is a growing body of evidence that the processes mediating the allocation of spatial attention ...
Upon binding of cAMP, the biosensor signal decreases due to a conformational change that increases the distance between the donor and acceptor (Fig. 3A, left). The reduction in the BRET signal upon treatment with forskolin (FSK) in HEK293 cells expressing WT or mutant APJ was significantly ...
然而,scRNA-seq需要一个解离(dissociation step)步骤来获得细胞悬液( cell suspension),导致空间背景的丧失。空间的保持对于理解细胞特征和重建正常生理(normal physiology)或扰动(perturbation)下的组织结构至关重要. 为了阐明单细胞的异质性和定义细胞类型,同时也保留空间信息,最近开发了一些方法来描述空间分辨率的转录组...
We utilized the run_kdist function from the CellTrek package to calculate the spatial k-distance between different cell types. The analysis followed the parameters: ref_type = "all", keep_nn = F, k = 10. Comparison dendrograms ...
we find that in our scRNA-seq data the cell type compositions inferred for endogenous, contamination and empty counts are by and large similar with a slight increase in the PT-profile in empty droplets, suggesting that this cell type is more vulnerable to dissociation procedure than other cell ...
a, Obtained from surgically extracted brain, serial tissue sections are imaged for 3D MSI using a fast acquisition strategy, and single-cell populations prepared by tissue dissociation are probed with high-throughput image-guided MS. b, A deep-learning model reconstructs high-mass-resolving and hig...
The dissociation constant (KD) value indicating the binding affinity of the RBD of the SARS-CoV-2 S protein to soluble ACE2 when expressed on yeast is shown. b Pseudovirus assay. HOS-ACE2/TMPRSS2 cells were infected with pseudoviruses bearing each S protein. The amount of input virus was...