synthesisThe Diels–Alder reaction has both enabled and shaped the art and science of total synthesis over the last few decades to an extent which, arguably, has yet to be eclipsed by any other transformation in the current synthetic repertoire. With myriad applications of this magnificent ...
A Synthesis of trans-9Methyl6-octalin-1,4-dione in the methylmercaptotoluquinone structures and the latter have been utilized in the Diels-Alder reaction with butadiene to synthesize trans-9-methyl-螖6-octalin-1,4-dione, an intermediate of potential utility in steroid total synthesis... V ...
2005 . A Diels-Alder reaction for the total synthesis of the novel antibiotic antitumor agent mensacarcin . Eur J Org Chem 2005: 2459 – 2467 .Lutz F.Tietze,CarlosGüntner,Kersten M.Gericke,IngridSchuberth,GaborBunkoczi.A Diels–Alder Reaction for the Total Synthesis of the Novel Antibiotic ...
This step establishes the proper arrangement of the required four contiguous stereocenters, including the quaternary center, and represents the first successful application of an enantioselective organomediated Diels−Alder reaction in total synthesis....
Herein, we highlight possible applications of the Diels–Alder reaction in pharmaceutics and biomedical engineering. Particular focus is placed on the synthesis of polymers and dendrimers for drug delivery, the preparation of functionalized surfaces, bioconjugation techniques, and applications of the Diels...
Diels-Alder反应,反电子要求的Diels-Alder反应和 Hetero-Diels–Alder reaction(杂-Diels–Alder反应) 都是[4+2]环加成反应,都属于协同反应。是由共轭双烯与亲双烯体构建环己烯骨架的经典反应。反应有丰富的立体化学呈现,兼有立体选择性、立体专一性和区域选择性等。该反应是可逆反应,正向成环的反应温度较低,逆向...
Total Synthesis of (±)-Crinine via the Regioselective Stille Coupling and Diels−Alder Reaction of 3,5-Dibromo-2-pyrone 喜欢 0 阅读量: 24 作者:Nguyen,Thanh,Tam,Cheon-Gyu,Cho 摘要: The regioselective synthesis and Diels−Alder cycloaddition of 3-(3,4-methylenedioxyphenyl)-5-bromo-2-...
Total synthesis of (±)-lysergic acid by an intramolecular imino-Diels-Alder reaction. Helv. Chim. Acta 64, 478–481 (1981). Article CAS Google Scholar Ramage, R., Armstrong, V. W. & Coulton, S. A new synthetic route to (±)-lysergic-acid. Tetrahedron 37, 157–164 (1981). ...
The transannular Diels–Alder strategy: applications to total synthesistransition metalcluster complexchiralcrystal structureenantiomeric separationdiastereoisomersGraphicdoi:10.1016/S0040-4020(01)00121-1Eric MarsaultAndrás ToróPawel NowakPierre Deslongchamps...
ChemInform Abstract: Diels〢lder Reactions of Heterocyclic Azadienes: Development of a Strategy for the Total Synthesis of Streptonigrin, Lavendamycin, and Synthetic Quinoline8﹒uinonesorganic chemistry, reviewantibioticsdoi:10.1002/chin.199003333BOGER...