In single cell analysis, DDX3Y was expressed consistently across differ- ent cell types such as trophoblasts, stromal cells and Hof- bauer cells in early pregnancy with a male fetus [33–35]. X chromosome expression in the male placenta While the majority of upregulated genes in early ...
Gene expression from the Y chromosome is detected in early CV samples, withDDX3Y,EIF1AY, KDM5D,PCDH11Y,RPS4Y1,USP9Y,UTY, andZFYexpressed consistently in males across datasets (Fig.1). Additionally, transcriptsNLGN4Y, TBL1Y, andTMSB4Ywere detected in a similar analysis which sequenced a b...
Gene expression from the Y chromosome is detected in early CV samples, withDDX3Y,EIF1AY, KDM5D,PCDH11Y,RPS4Y1,USP9Y,UTY, andZFYexpressed consistently in males across datasets (Fig.1). Additionally, transcriptsNLGN4Y, TBL1Y, andTMSB4Ywere detected in a similar analysis which sequenced a b...
Unlike the mutant, wild-type DHX9 interacts with R-loop-associated proteins such as PARP1 and DDX21 via SUMO-interacting motifs. Fusion of SUMO2 to the DHX9 K120R mutant enhances its association with these proteins, reduces R-loop accumulation, and alleviates survival defects of DHX9 K120R....
Because Ddx4-Cre-mediated recombination begins at E15, when oocytes are in MPI, we assessed whether the Ddx4-Cre mediated loss of PRC1 affects MPI progression. At P1 and P5, similar populations of germ cells reached the dictyate stage both in PRC1cKO and PRC1 control (PRC1ctrl) ovaries...
The tree begins at the root device node, which represents the platform. Below the root node are the branches of the device tree. A branch consists of one or more bus nexus devices and a terminating leaf device. A bus nexus device provides bus mapping and translation services to subordinate ...
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genes perform an array of regulatory functions and belong to diverse clasess such as histone lysine demethylases (KDM5DandUTY); the transcription factor (ZFY), spliceosomal component (RBMY); translation initiation factors (DDX3YandEIF1AY); and the deubiquitinase (USP9Y) suggesting that the genes...
with FADD (Fas-associated via death domain), which is activated upon binding to cell death receptors responding to their ligands. DNA damage, hypoxia, metabolic stress, and other factors can induce intrinsic apoptosis, which begins with MOMP and leads to the release of mitochondrial proteins (e...
Recently, an association of gene fusion involving USP9Y (TTTY15-USP9Y) with prostate cancer has also been reported [70] suggesting its functions beyond regulation of sperm production. DEAD [asp-glu-ala-asp] box RNA helicases, Box 3, Y-linked [DBY] DBY, also known as DDX3Y, was ...