1c,d and Extended Data Fig. 2a). The extent of growth reduction depended on the light duration, showing that the cellular response was proportional to the amount of telomeric damage (Extended Data Fig. 2b). Parental hTERT BJ and RPE cells lacking FAP-TRF1, and FAP-TRF1-expressing HeLa ...
in which acidic residues of the putative catalytic center, expected to coordinate divalent cations, were replaced by alanines (D90A and D92A;FAM46Cmut). This was followed by an in vitro polyadenylation assay using a A15oligoribonucleotide RNA as a substrate. Wild type, but ...
Using survey data that revealed whether respondents voted in national elections and how knowledgeable respondents are about politics, Charles and Stephens claim that the likelihood of voting is driven in part by potential voters' confidence in their assessments of candidates—essentially, the more ...
Note: Data was originally obtained from http://flyatlas.org and values shown were extracted from Luan and Li [24]. Values indicate intensities of RNA signal. N/A: no informative data. Enrichment is defined as the mRNA expression of the tissue/whole body mRNA expression. Several recent lines...
In conclusion, our data shows that the NES region of NS1 plays an extremely important role during influenza A virus infection. It was clearly shown that the NES sequence regulates the nucleo-cytoplasmic transport of NS1. An association with nuclear retention of NS1 and increased phosphorylation of...
SN ratio is a value-assessing tool in the quality engineering, using the unit of dB. It adopts the ratio of useful data (signal) to harmful data (interference) to assess function. After conducting some adjustment on the interference factors, SN ratio could capture the size of signal impact....
It was noted that the regulatory regions of theboPAGsdo not share any conserved sequences with other genes whose expression is restricted to trophoblast (data not shown). This analysis sought to improve the understanding of the proximal promoters ofboPAGsand identify any conserved elements within ...
Taxonomic classification was performed using Kraken 2 v2.0.8-beta [151] with confidence thresholds of 0–0.5 at 0.1 intervals (data shown in the main text use a confidence threshold of 0.3) with a database built using all sequences in the NCBI RefSeq release 205 [152]. Bracken v2.5.0 ...
Hydroxychloroquine (HCQ), a drug used to treat lupus and malaria, was proposed as a treatment for SARS-coronavirus-2 (SARS-CoV-2) infection, albeit with controversy. In vitro, HCQ effectively inhibits viral entry, but its use in the clinic has been hampe
One representative experiment is data shown as mean values ± one SD. b Time course of α-1,4-(GalNAc)7 deacetylation by Agd3 or Agd3W344A. Products were analyzed by MALDI-TOF MS and graphed as the relative amount of unmodified substrate. The average number of deacetylation events ...