The discovery will aid in diagnosis of the genetic disorder, and can lead to improved therapy or possibly new drugs or gene therapy. INSET: The cf gene hits the news..MarxJ.L.ScienceMarx, J.Ll., " The Cystic Fibrosis Gene is Found, " Science 245:923-925 (Sep. 1, 1989)....
Overlapping complementary DNA clones were isolated from epithelial cell libraries with a genomic DNA segment containing a portion of the putative cystic fibrosis (CF) locus, which is on chromosome 7. Transcripts, approximately 6500 nucleotides in size, were detectable in the tissues affected in ...
The cystic fibrosis gene, IgE and IgG4 来自 NCBI 喜欢 0 阅读量: 11 作者:F Carswell,J Oliver,M Silverman 摘要: Two tensile-strained GaxIn1-xP / InP (001) heterostructures (with x = 6.5% and x = 11.2%) have been studied by TEM and cathodoluminescence. In both structures stacking ...
Cystic fibrosis (CF) is a single-gene disorder with insufficient treatment options and a target organ, the lung that is relatively easily accessible. Thus, it is not surprising that in the early years of gene therapy, CF was at the forefront of this field. Since cloning of the CF gene in...
The author summarizes research on cystic fibrosis carried out since the discovery of the defective gene in 1989. As a result of this work, the molecular basis of the disease is known in considerable detail. As well, the nature of the functional defects in the cells of people with cystic fib...
Cl- channel activity in Xenopus oocytes expressing the cystic fibrosis gene. The expression of the cystic fibrosis (CF) gene on its introduction into nonepithelial somatic cells has recently been shown to result in the appearance of... CE Bear,F Duguay,AL Naismith,... - 《Journal of Biologic...
cystic fibrosis - the most common congenital disease; the child's lungs and intestines and pancreas become clogged with thick mucus; caused by defect in a single gene; no cure is known fibrocystic disease of the pancreas, mucoviscidosis, pancreatic fibrosis, CF monogenic disease, monogenic disord...
Genetics is the branch of biology concerned with study of individual genes and how they work whereas genomics is involved with the analysis of all genes and their interactions. Both of these approaches have been applied extensively to CF. Identification of the CFTR gene initiated the dissection of...
Cystic FibrosisPrenatal DiagnosisNo Abstract available for this article.doi:10.1038/311104a0vanHeyningenVeronicaNature Publishing Group UKNatureVAN HEYNIGEN, V. (1985). Cystic fibrosis: In search of the gene. Nature (London) 311: 104-105.
Cystic fibrosis: molecular diagnosis, population screening, and public policy. To review the current status of scientific knowledge and opinion regarding molecular genetic testing of mutations in the CFTR gene for purposes of diagnosi... WW Grody - 《Archives of Pathology & Laboratory Medicine》 被...