From the overall results, we concluded that one of the smallest acyclic guest molecules, isopentane, participating in the formation of a structure-H clathrate hydrate is encaged, confirming the gauche conformat
Quick note on these rings: As you well know, these rings are not actually flat, like they are shown on this page. They each have a preferred conformation, as you will see in great detail with cyclohexane as you proceed in organic chemistry. In fact, here is a conformation of cyclooctane...
As a conclusion, the structural investigation of P25 in its native environment may contribute to the elucidation of new elements concerning the conformation of the MIP family proteins. P25 shares common structural and biochemical features especially with AQP1 and MIP26. It also shows original partic...
Double-strand breaks in the mitochondrial DNA (mtDNA) result in the formation of linear fragments that are rapidly degraded. However, the identity of the nuclease(s) performing this function is not known. We found that the exonuclease function of the mtDNA polymerase gamma (POLG) is required fo...
The depletion of chondroitin sulfates (CSs) within the intervertebral disc (IVD) during degenerative disc disease (DDD) results in a decrease in tissue hydration, a loss of fluid movement, cell apoptosis, a loss of nerve growth inhibition and ultimately, the loss of disc function. To date, li...
Finally, the virtual constructs were run through an mFold analysis (https://www.rna.albany.edu/unafold-web-server-discontinued) to ensure that the hairpin structures maintain the expected conformation. Once cloned under the control of the U6-1, a strong and constitutively active Pol III promoter...
Article Open access 23 April 2025 Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration Article Open access 18 November 2022 Introduction Cell fusion is a fundamental process required for sexual reproduction and for the development of many bod...
According to this model, overexpression of Munc18 would inhibit vesicle fusion by maintaining syntaxin in the closed conformational state, whereas complete displacement of Munc18 would prevent the interconversion between the open and closed conformation, suggesting the necessity of the transition state for...
Epsins 1 and 2 function as molecular bridges to bind epidermal growth factor pathway substrate 15 (Eps15) and clathrin adaptor protein-2 (AP-2), allowing the appropriate molecular conformation required for assembly of the coated pit. Indeed, perturbation of epsin function in fibroblasts potently ...
Rotation isomerism is caused by limited rotation of atoms or groups of atoms in a molecule around a C—C or other single bond. The geometric forms thus assumed by the molecule are called conformations, and the corresponding structures are called conformers (conformation or rotation isomers). The...