Building on this knowledge, introduction of anthocyanin-related glutathione transferases into a heterologous biosynthetic pathway in baker’s yeast results in >35-fold increased anthocyanin production. In addition to unravelling the long-elusive anthocyanin biosynthesis, our findings pave the way for the ...
Magnetic targeting is a directional method that utilizes a magnetic field to guide the movement of drug-loaded magnetic microparticles to the site of a lesion [111]. By integrating magnetic substances into drugs, a magnetically targeted formulation may be created that can be directed through blood ...
cisplatin resistance poses a significant challenge to achieving optimal therapeutic outcomes in patients undergoing chemotherapy for lung cancer. Natural products have gained prominence as a valuable adjunct in the comprehensive treatment of various malignancies. Besides, natural products have been shown to p...
we employed MSCs, which can self-renew and resume colony-based proliferation even after exposure to environmental stresses34, likely due to the heterogeneity of damage, with cells experiencing less damage presumably able to retain the potential to self-recover and re-enter the cell cycle24,...
Teschke R, Danan G. Worldwide use of RUCAM for causality assessment in 81,856 idiosyncratic DILI and 14,029 HILI cases published 1993-mid 2020: a comprehensive analysis. Medicines (Basel). 2020;7(10):62.https://doi.org/10.3390/medicines7100062((PMID:33003400; PMCID:PMC7600114)). ...
22. We combined these datasets with several in-house studies to create a comprehensive collection of 988 samples (764 tumour samples and 224 adjacent normal samples) across 11 different cancer types, covering 15 datasets, which we called the CAMP (Table1and Fig.1a). The overall collection ...
However, these previous investigations were mostly predictive and lacked comprehensive analysis of the detoxifying organ liver and experimental validation, thus reducing the trust in the conclusions. To address these issues, we performed single-cell sequencing and metabolomic analysis on liver tissue from ...
The mentioned loop could motivate the authors from other geographical regions, where the Grewia species also grows, to join the international ethno-geo-pharmacological investigation and to provide a comprehensive evaluation of the bio-potency by applying a unified methodology. Providing a unified ...
Meanwhile, efforts are made to give a comprehensive overview of the recent advances of the implication of cellular senescence in CKD. To date, numerous studies have focused on the effects of ageing risk factors in kidney and thereby trying to interrupt the kidney ageing processes with senolytics....
C. glabratadownregulated ROS detoxifying genes upon echinocandin exposure27. To ask whether ROS are involved in persistence and emergence of ECR mutants, we deleted genes with well-known functions in ROS detoxification: catalase (CAT1, CAGL0K10868g), glutathione oxidoreductase (GRX2, CAGL0K05813g...