Cryptic female choice, though a subtle and complex process, has deep evolutionary significance with the potential to impact the entire evolutionary landscape of reproduction. By favoring or disfavoring sperm of specific males, females can influence the traits of their offspring and improve own fitness...
In aged astrocytes, the levels of major histocompatibility complex (MHC) class I/II genes (B2m, H2-D1, Cd74 and MHCII genes involved in adaptive immunoregulation) and the complement cascade gene C4b were markedly elevated (Supplementary Fig. 9b and Supplementary Table 6). However, Occludin, ...
The SLC2 genes code for a family of GLUT proteins that are part of the major facilitator superfamily (MFS) of membrane transporters. Crystal structures hav
which combines big data, advanced bioinformatic tools, network science, systems biology, artificial intelligence, and clinical biometric data to investigate the pathogenesis of complex diseases such as cancer and CVDs.
15 gene duplication events were detected in 12 independent trees. Arrow indicates a gene duplication event with the divergence time (Myr ago). The index in SLC25 (the appellation of MCF in human) was used to denote the corresponding orthologous sequences, such as A7, 8, 9 (representing the...
The mechanistic (previously mammalian) target of rapamycin (mTOR) is a highly conserved Ser/Thr kinase that acts as the catalytic subunit of two structurally and functionally distinct large multiprotein complexes, referred to as mTOR complex 1 (mTORC1) and mTORC2. Both mTORC1 and mTORC2 play ...
On the cellular level, zinc is essential for proliferation and differentiation, but zinc homeostasis is also involved in signal transduction [5,6] and apoptosis [7]. Cells depend on a regular supply of zinc and make use of a complex homeostatic regulation by many proteins [8], but the plasm...
1. Introduction: Clinically Relevant Transporters of the SLC Family and Implications in Drug Discovery 2. Molecular Modeling Approaches at a Glance 3. Data Sparseness as a Major Challenge in Computer-aided Drug Discovery & Implications to the Exploration of Uptake Transporters 4. Linking Ligand- and...
[15]. Moreover, the experimental results proved that mitophagy could protect cells from ferroptosis [16]. Nevertheless, increasing evidence suggests that the relationship of mitochondrial quality control with metal ion-dependent cell death is not simply inhibitory but multifactorial, involving complex ...
Importantly, PAI-1 mRNA and protein levels show a clear circadian variation.39,40 Consistent with this result, plasma levels of the plasmin–plasmin inhibitor complex decreases in the morning.41 These results imply that the mismatch between coagulation and fibrinolytic activity may elicit the onset ...