Each of these three genes encodes a protein with an myeloblastosis-like deoxyribonucleic acid-binding (DNA-binding) domain that lacks a transcriptional activation domain. These three genes have overlapping functions during root hair differentiation in Arabidopsis52, so their loss may also underlie root...
Several changes were introduced to the entity formerly designated AML with myelodysplasia-related changes, now calledAML, myelodysplasia-related(AML-MR). This AML type is defined as a neoplasm with ≥20% blasts expressing a myeloid immunophenotype and harboring specific cytogenetic and molecular abnorma...
such as “Seurat” and “SingleCellExperiment” provide similar functions to get a normalized (log-transformed) or scaled matrix. For improved variance stabilization, the Seurat team has recently introduced SCTransform, a method that employs regularized negative binomial regression for...
The DAR refers to the number of effective payload molecules carried by each antibody and is another important factor related to the activity of the ADC. Once the best linker has been selected for the ADC, it is important to determine the ideal number of conjugates to the antibody. A very l...
HIF signaling enhances the maintenance of a CSC phenotype through the regulation of octamer-binding transcription factor 4 (Oct4), sex determining region Y box 2 (SOX2), kruppel-like factor 4 (KLF4), myelocytomatosis oncogene product (Myc), Tir nan Og (NANOG) and polycomb complex protein BMI...
However, severe side effects such as nephrotoxicity, myelotoxicity and drug resistance limit its application [164]. The combined delivery of DDP and β-E has been considered a potentially effective strategy to enhance efficacy, reduce toxicity and overcome resistance. Cao et al. [165] prepared co...
Careful interpretation of the AML arm of the PANTHER trial is required as patients with a blast percentage > 30% were excluded and results of AML patients are analyzed together with results from patients with high-risk myelodysplastic syndrome (HR-MDS) or chronic myelo-monocytic leukemia (CMML)....
215,216 JAK2 mediates myelopoietic formation at different stages through its interactions with various receptors (e. g. EPO, TPO, and GM-CSF).135 In addition, the combined actions of JAK1 and JAK2 are crucial for lymphopoiesis. Both JAK1 and JAK3 can bind to IL-2R, IL-4R, IL-7R, ...
recent studies have increasingly focused on the extent to which structure and function are coupled across brain regions1,2,3. A brain region’s ‘structure-function coupling’ (SFC) refers to the manner in which its functional and structural connectivity statistically depend upon one another. Here...
Yan et al., “Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors,” Science, 290:523-527 (2000). Youn et al., “Isolation and Characterization of LMC, a Novel Lymphocyte and Monocyte Chemoattractant Human CC Chemokine, with Myelosuppress...