one of two or more alternative forms of a gene occupying the same position on matching chromosomes: an individual normally has two alleles for each trait, one from either parent. [1930–35; < GermanAllel,appar. as shortening of German equivalents ofallelomorphorallelomorphic gene] ...
Alleles that have a detrimental effect on the phenotype of an individual. Mutational load The mutational burden in a population or an individual resulting from deleterious variants. Relaxed selection The weakening or removal of a selective pressure, such as when domesticated animals are less subject ...
T-lineage acute lymphoblastic leukaemia (T-ALL) is a high-risk tumour1 that has eluded comprehensive genomic characterization, which is partly due to the high frequency of noncoding genomic alterations that result in oncogene deregulation2,3. Here we report an integrated analysis of genome and tra...
Data presented here document the molecular biology, genomic composition and phylogenetic placement of a newly discovered Theileria pathogen that has serious implications for diagnosis of Theileria infections in equids. Equine piroplasmosis (theileriosis), caused by Theileria equi, is a tick-borne ...
Inheritance of the mutation does not follow any simple Mendelian pattern but almost certainly involves the segregation of one or more recessive alleles. The achiasmatic mutation displays a pattern of misrouting of optic axons opposite to that seen in albinos, in which an excess of fibers cross ...
Several previous studies have identified a potential role that the gut microbiome can play in autism spectrum disorder (ASD) in children, but little is known about how variations in the virome may be involved in ASD. We aimed to understand the changes in the gut DNA virome of children with...
(mainlyM. m. domesticus), or the presence of artificial selection during mouse domestication, or a combination of all factors. The clustering of classical inbred strains with the wildM. m. domesticusis consistent with the view that the classical inbred mice predominately originate from this ...
(CCA), which extracts the linear combination of those dimensions that maximally correlates with the state of a given single nucleotide polymorphism (SNP). In total, 10,647,531 SNPs across the genome were tested in a US cohort comprising of rich ancestral diversity. After applying quality control...
Ongoing studies in many species seek to understand the origins, architecture and consequences of phenotypic variation under normal and dysfunctional conditions, with the aim of identifying targets for intervention that can prevent, stabilize or reverse d
Therefore, the assessment of asymmetry as an indicator of the qualitative implementation of the generative development program seems to be decisive. One can assume various reasons for this effect, but the most obvious is the assumption that the seeds do not have the property of an ideal model; ...