The chemistry of the vitamin B3 metabolomedoi:10.1042/bst20180420Mikhail V. MakarovSamuel A.J. TrammellMarie E. MigaudBiochem Soc Trans
The purpose of this review is to summarize the research to date on the impact of chronic kidney disease (CKD) on the vitamin K metabolome. Vitamin K-dependent proteins contribute to cardiovascular disease (CVD) prevention via the prevention of ectopic mineralization. Sub-clinical vitamin K deficien...
The bioactive form of nicotinic acid (vitamin B3) is nicotinamide, which is an important coenzyme in the body. Nicotinic acid metabolism can affect choline metabolism through betaine and glycine metabolism [46]. There are two main sources of nicotinamide: one is from food, and the other is ...
The joint study of microbiome and metabolome has been suggested as the most promising approach to evaluate host–microbiome interactions10. However, studying the metabolic holobiont is complex, and few studies have tackled this issue in humans at any scale. Our group previously used 16S rRNA gene ...
Age-related osteoporosis is characterized by reduced bone mineralization and reduced bone strength, which increases the risk of fractures. We examined metabolic changes associated with age-related bone loss by profiling lipids and polar metabolites in tibia and femur bone tissues from young (5 months ...
This limitation has mostly arisen because metabolomics has, until recently, lacked the electronic database equivalent of GenBank or UniProt [2] for compound identifica- tion. With the release of the Human Metabolome Database (HMDB) [4,5] and other related compound or spectral resources such as...
2022, Journal of Biological Chemistry Citation Excerpt : Increased hepatocyte fatty acid oxidation is likely responsible as the lysine-acetylated proteins can be normalized by feeding PcxL−/− mice a ketogenic diet. Although much has been written regarding the posttranslational regulation exerted by...
Metabolomics reflects the plant status at a given point, enables the detection of changes imperceptible by phenotype-based biomarkers, and, as metabolites are the final product of gene and protein expression despite the metabolome not being fully associated with the plant genome, enlightens about NP...
2.8. Physiological and Clinical Significance of Vitamin D Metabolites—A Review Even though over 50 different vitamin D metabolites have been described so far, which enables us to speak of a whole vitamin D metabolome, only 1α,25(OH)2D has been generally recognized as biologically active. By ...
Cancer is defined by the WHO (World Health Organization) as a group of diseases caused by abnormal, uncontrolled cell growth, which can be located in almost any organ or tissue of the body.1 The pr...