transfer RNAs (tRNAs), small nuclear RNAs (snRNAs), and small nucleolar RNAs (snoRNAs)) were the first ncRNAs to be identified and studied. They are up to ~4.5 kb long and ubiquitously expressed, as they are involved in essential processes...
Magnesium (Mg2+) is the 2nd most abundant intracellular cation, which participates in various enzymatic reactions; there by regulating vital biological fun
The SuperCam instrument is a response to this requirement for remote mineralogy while preserving the ability to remove dust prior to making observations of nearby targets, and providing the same or better chemistry and high-resolution imaging as ChemCam. This new instrument resulted from a happy coll...
Drug discovery Medicinal chemistry New modalities Artificial intelligence Societal impact Introduction The year 2021 marks the 125th anniversary of the Bayer Chemical Research Laboratory in Wuppertal, Germany (Fig. 1).1., 2. This research facility has been vital for Bayer’s continuing development. Whe...
Historically, the generation of tree-ring records for the tropics has lagged considerably behind temperate to higher latitude regions of the globe, due to the fact that many tropical tree species (as a result of decreased temperature seasonality near the equator), do not form well-defined annual...
et al. Remnants of medieval field patterns in the Czech Republic: Analysis of driving forces behind their disappearance with special attention to the role of hedgerows. Agric. Ecosyst. Environ. 129, 465–473 (2009). Google Scholar Rippon, S. Historic Landscape Analysis: Deciphering the ...
co-founded the RAN with two other veterans from the former Protein Engineering Department at Genentech Inc.Sachdev Sidhu, PhD, now a professor of molecular genetics at the University of Toronto, andJames Wells, PhD, professor of pharmaceutical chemistry in the UCSF School of Pharmacy, teamed with...
Then the mAb underwent copper-free click-chemistry with appropriately functionalized linker-payload generating an ADC with a DAR of 4.3. In addition to these conjugation strategies, the galactose residue was also explored as a modification site. Multiple studies reported the removal of galactose using...
In the case of the interaction of iron and HS, the common paradigm in aquatic chemistry is that all HS binding sites are weak and can hardly compete against natural ligands of biological origin and higher affinity for iron (Whitby et al., 2020b). The origin of such a belief is the init...
The chemistry behind catechol-based adhesion. Angew. Chem. Int. Ed. 2018, in press. [CrossRef] 6. Della Vecchia, N.F.; Avolio, R.; Alfè, M.; Errico, M.E.; Napolitano, A.; d'Ischia, M. Building-block diversity in polydopamine underpins a multifunctional eumelanin-type platform ...