biology Review The Consequences of Chromosome Segregation Errors in Mitosis and Meiosis Tamara Potapova 1 and Gary J. Gorbsky 2,* 1 Stowers Institute for Medical Research, Kansas City, MO 64110, USA; tpo@stowers.org 2 Cell Cycle and Cancer Biology Research Program, Oklahoma Medical Research ...
The seven upregulated genes for cultures with many colonies, on the other hand, include genes that are linked with mitosis (KIAA1383 and PARD6A), invasion and metastasis (LMLN and PARD6A), and protein folding (HSPA12A). The most interesting gene, however, might be the proto-oncogene GRB10...
Intermolt Cryptocercus typically harbor the trophozoite stage, which reproduces by mitosis. Flagellates change from asexual to sexual methods of reproduction (i.e., initiate an SE cycle) at the time their host enters its molting period. The molting period of Cryptocercus begins with the ...
Intriguingly, JSI-124 caused the accumulation of G2/M phase to regulate cell cycle, confirmed by MPM-2 staining and increased protein synthesis during mitosis by mitotic index analysis. Western blot analysis found that JSI-124 affected the progression of G2/M arrest by downregulating the CDK1...
GFP-NE81∆CLIM clusters underwent cell-cycle-dependent assembly/disassembly. Point mutation of the CDK1 phosphorylation site at position 122 to prevent CDK1 phosphorylation abrogated this dynamic behavior and prevented disassembly at the onset of mitosis. In strains expressing GFP-NE81 without a ...
cancers Article The Enrichment of Survivin in Exosomes from Breast Cancer Cells Treated with Paclitaxel Promotes Cell Survival and Chemoresistance Bridget T. Kreger 1, Eric R. Johansen 1, Richard A. Cerione 1,2,* and Marc A. Antonyak 1 1 Department of Molecular Medicine, Cornell University, ...
410 East Saint Mary Boulevard, Lafayette, LA 70503, USA; masood.sepehrimanesh@louisiana.edu * Correspondence: Baojin.Ding@Louisiana.edu Abstract: Nucleocytoplasmic transport (NCT) across the nuclear envelope is precisely regulated in eukaryotic cells, and it plays critical roles in maintenance of cel...
marine drugs Article The In Vitro Anti-Tumor Activity of Phycocyanin against Non-Small Cell Lung Cancer Cells Shuai Hao 1, Yan Yan 1, Shuang Li 1, Lei Zhao 1, Chan Zhang 1, Liyun Liu 2,* and Chengtao Wang 1,* ID 1 Beijing Advanced Innovation Center for Food Nutrition and Human ...
Mechanism of G1-like arrest by low concentrations of paclitaxel: Next cell cycle p53-dependent arrest with sub G1 DNA content mediated by prolonged mitosis. Oncogene 2008, 27, 4402–4410. [CrossRef] [PubMed] 20. Xi, G.; Hu, X.; Wu, B.; Jiang, H.; Young, C.Y.; Pang, Y.; ...
Cyclin B2, encoded by Ccnb2, binds to cyclin-dependent kinase 1 (also known as Cdc2) and regulates the events during both the G2/M transition and progression through mitosis. Cdc6 is a key regulator in the early steps of DNA replication, as the binding of Cdc6 to chromatin is a ...