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Immune checkpoint inhibitors The interaction of PD1 expressed in T cells with PD-L1 on cancer cells suppresses the proliferation and survival of T cells, which ultimately leads to immunosuppression. Pembrolizumab and nivolumab are ICIs that target PD1 to prevent PD1/PD-L1 interaction [19]. In cont...
Cellular plasticity cascades: genes to behavior pathways in the pathophysiology and treatment of bipolar disorder. In: Charney DS, Nestler EJ (eds). Neurobiology of Mental Illness. Oxford University Press: New York. Cecil KM, DelBello MP, Morey R, Strakowski SM (2002). Frontal lobe differences...
In addition, many reports have shown that several protein kinases affect the CaSR-induced signaling cascades (Awata et al., 2001; Sakwe et al., 2004). Therefore, extensive investigations on the relationship between protein kinase and the CaSRs in MMCs will be necessary. Mesangial cell ...
The neurotrophic factor BDNF is an important regulator for the development of brain circuits, for synaptic and neuronal network plasticity, as well as for
These experiments also demonstrate that preantral granulosa cells are competent to generate MAPK signaling cascades in response to EGF (Fig. 7) and together with CEEF exposure are able to upregulated some of the cumulus expansion-related genes (Fig. 4, Fig. 5). However, although preantral ...
As stated above, TFs can have oncogenic or tumour suppressor properties, acting on various key molecular cascades involved in CRC pathogenesis. Classically, except for ligand-inducible nuclear receptors, TFs have been described as “undruggable” targets. However, several recent approaches aiming to reg...
Epicardial signaling cascades are essential for cardiac lineage specification67. During embryonic development, cells from the proepicardial organ (PEO), an extra-cardiac cluster of embryonic cells68, migrate to the surface of the heart to form the epicardium. Some of these cells can undergo ...
Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades. EMBO J 1999; 18:6962-6972. 11 Gechtman Z, Alonso JL, Raab G, Ingber DE, Klagsbrun M. The shedding of membrane-anchored heparin-binding epi...