Figure 1. The Cancer-Immunity Cycle In cancer patients, the cycle is not operating properly. For example, tumor antigens may not be detected correctly by dendritic cells, or the tumor microenvironment might suppress the effector cells that ...
Tumor specific antigensAntigen-presenting cellsMajor histocompatibility complexcancer-immunity cyclecancer treatmentsThis review presents a comprehensive introduction of the Cancer-Immunity Cycle of TSAs.TSAs are identified by a variety of methods, laying the foundation for highly targeted TSAs-based ...
CAR）工程应用于自体 T 细胞，开创了合成癌症免疫（synthetic immunity to cancer）的先河。CAR...
These immunotherapies often act on a single step of the cancer–immunity cycle. In recent years, the discovery of new nanomaterials has dramatically expanded the functions and potential applications of nanomaterials. In addition to acting as drug-delivery platforms, some nanomaterials can induce the ...
Oncology meets immunology: the cancer-immunity cycle. Immunity 39, 1–10 (2013). Article PubMed CAS Google Scholar Carrega, P. et al. CD56brightperforinlow noncytotoxic human NK cells are abundant in both healthy and neoplastic solid tissues and recirculate to secondary lymphoid organs via ...
Immunity 2013 Chen DS et al 感慨!神作发表已经快到10年,CTLA-4和PD-1/PD-L1仍在C位。2022年,Relatlimab-rmbw作为全球首款获批LAG-3抗体,成为10年来获批的第三种免疫检查点抑制剂。随后,全球首款PD-1/CTLA-4双特异性抗体卡度尼利AK104在中国获批。治疗性癌症疫苗仍在探索,CAR-T(细胞治疗)2017年首次获...
The cancer immunity cycle has become the framework for cancer immunotherapy research. Learn the steps of the cycle here.
Here we combine lipid nanoparticle–mRNA formulations and dendritic cell therapy (named CATCH) to boost the cancer–immunity cycle via progressive steps to overcome the immunosuppressive tumour microenvironment. Multiple types of sugar-alcohol-derived lipid nanoparticles are conceived to modulate the cancer...
OncologyMeetsImmunology:TheCancer-ImmunityCycle. dx.doi.org/10.1016/j.im 2. Immune checkpoint therapy—current perspectives and future directions. doi.org/10.1016/j.cell. 3. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. doi.org/10.1038/nm730 4. The ...
The Cancer-Immunity Cycle For an anticancer immune response to lead to effective killing of cancer cells, a series of stepwise events must be initiated and allowed to proceed and expand iteratively. We refer to these steps as the Cancer-Immunity Cycle (Figure 1). In the first step, neoanti...